Evidence map›Paper›PMID 35194026›Full record

ArticleNature communications2022

Organic electrochemical neurons and synapses with ion mediated spiking.

Padinhare Cholakkal Harikesh, Chi-Yuan Yang, Deyu Tu, Jennifer Y Gerasimov, Abdul Manan Dar, Adam Armada-Moreira, Matteo Massetti, Renee Kroon, David Bliman, Roger Olsson and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed.

  1. Review
  2. Ion-Exchange-Driven Ternary Organic Neuromorphic Devices with High Efficiency and Stability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Battery-Inspired Electrochemical Synapses for Neuromorphic Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. An organic artificial cardiomyocyte.Nature communications · 2026
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Broadly applicable hydrophilic additive enhances electrochemical transistor function.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  17. Article
  18. Article
  19. Review
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Padinhare Cholakkal Harikesh *Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden.ORCID 0000-0002-2488-1821
Chi-Yuan Yang *Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden.ORCID 0000-0003-4270-1131
Deyu TuLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden.ORCID 0000-0002-8875-408X
Jennifer Y GerasimovLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden.
Abdul Manan DarLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden.
Adam Armada-MoreiraLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden.
Matteo MassettiLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden.
Renee KroonLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden.
David BlimanDepartment of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96, Gothenburg, Sweden.ORCID 0000-0003-0487-8366
Roger OlssonDepartment of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96, Gothenburg, Sweden.ORCID 0000-0002-7107-3472
Eleni StavrinidouLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden.ORCID 0000-0002-9357-776X
Magnus BerggrenLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden.ORCID 0000-0001-5154-0291
Simone FabianoLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden. simone.fabiano@liu.se.ORCID 0000-0001-7016-6514

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Future brain-machine interfaces, prosthetics, and intelligent soft robotics will require integrating artificial neuromorphic devices with biological systems. Due to their poor biocompatibility, circuit complexity, low energy efficiency, and operating principles fundamentally different from the ion signal modulation of biology, traditional Silicon-based neuromorphic implementations have limited bio-integration potential. Here, we report the first organic electrochemical neurons (OECNs) with ion-modulated spiking, based on all-printed complementary organic electrochemical transistors. We demonstrate facile bio-integration of OECNs with Venus Flytrap (Dionaea muscipula) to induce lobe closure upon input stimuli. The OECNs can also be integrated with all-printed organic electrochemical synapses (OECSs), exhibiting short-term plasticity with paired-pulse facilitation and long-term plasticity with retention >1000 s, facilitating Hebbian learning. These soft and flexible OECNs operate below 0.6 V and respond to multiple stimuli, defining a new vista for localized artificial neuronal systems possible to integrate with bio-signaling systems of plants, invertebrates, and vertebrates.

Indexed as

Brain-Computer InterfacesRoboticsNeuronal PlasticityNeuronsSiliconSynapsesSilicon

Identifiers

PMID35194026
PMCPMC8863887

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.