Evidence map›Paper›PMID 35194017›Full record

ArticleNature communications2022

Fine-scale heterogeneity in population density predicts wave dynamics in dengue epidemics.

Victoria Romeo-Aznar, Laís Picinini Freitas, Oswaldo Gonçalves Cruz, Aaron A King, Mercedes Pascual

Erratum issuedAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  8. Variations in annual dengue intensities are explained by temperature anomalies.medRxiv : the preprint server for health sciences · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Victoria Romeo-AznarDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, USA.
Laís Picinini FreitasPostgraduate Program of Epidemiology in Public Health - Escola Nacional de Saúde Pública Sergio Arouca - Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.ORCID 0000-0001-9012-9382
Oswaldo Gonçalves CruzPrograma de Computação Científica - Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Aaron A KingDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-6159-3207
Mercedes PascualDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, USA. pascual@uchicago.edu.ORCID 0000-0003-3575-7233

Funding

Understanding Transmission with Integrated Genetic and Epidemiologic InferenceU54GM111274 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BEDFORD, TREVOR BC · 2014 to 2018
$12.5M
Dynamical modeling of hospital transmission and antibiotic resistance evolution in a multidrug resistant nosocomial pathogenR01AI143852 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOODS, ROBERT J · 2019 to 2023
$2.9M
NIAID NIH HHS R01 AI143852NIGMS NIH HHS U54 GM111274
6 · The paper itself

Abstract

The spread of dengue and other arboviruses constitutes an expanding global health threat. The extensive heterogeneity in population distribution and potential complexity of movement in megacities of low and middle-income countries challenges predictive modeling, even as its importance to disease spread is clearer than ever. Using surveillance data at fine resolution from Rio de Janeiro, we document a scale-invariant pattern in the size of successive epidemics following DENV4 emergence. Using surveillance data at fine resolution following the emergence of the DENV4 dengue serotype in Rio de Janeiro, we document a pattern in the size of successive epidemics that is invariant to the scale of spatial aggregation. This pattern emerges from the combined effect of herd immunity and seasonal transmission, and is strongly driven by variation in population density at sub-kilometer scales. It is apparent only when the landscape is stratified by population density and not by spatial proximity as has been common practice. Models that exploit this emergent simplicity should afford improved predictions of the local size of successive epidemic waves.

Indexed as

DengueEpidemicsBrazilHumansPopulation DensitySerogroup

Identifiers

PMID35194017
PMCPMC8864019

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.