ArticleProceedings of the National Academy of Sciences of the United States of America2022
Biocompatible surface functionalization architecture for a diamond quantum sensor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Quantum Dots for Biomedical Biosensing, NIR-II Bioimaging, and Phototherapy: Materials Design, Signal Transduction, and Translational Barriers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- What is quantum biology?Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Boron-doped diamond solution-gate field-effect transistor (BDD-SGFET) biosensor for gene mutation detection.Microsystems & nanoengineering · 2026Article
- Probing Cellular Activity Via Charge-Sensitive Quantum Nanoprobes.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- A Bayesian approach towards atomically-precise localization in fluorescence microscopy.Nature communications · 2025Article
- Advanced microfluidic systems with temperature modulation for biological applications.Biomicrofluidics · 2025Article
- Direct-bonded diamond membranes for heterogeneous quantum and electronic technologies.Nature communications · 2024Article
- Recent Advances in Transparent Electrodes and Their Multimodal Sensing Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Diamond surface functionalization via visible light-driven C-H activation for nanoscale quantum sensing.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Quantum-enhanced diamond molecular tension microscopy for quantifying cellular forces.Science advances · 2024Article
- Digital Magnetic Detection of Biomolecular Interactions with Single Nanoparticles.Nano letters · 2023Article
- Neuronal growth on high-aspect-ratio diamond nanopillar arrays for biosensing applications.Scientific reports · 2023Article
- Quantum sensors for biomedical applications.Nature reviews. Physics · 2023Review
- Diamond surface engineering for molecular sensing with nitrogen-vacancy centers.Journal of materials chemistry. C · 2022Review
- Advances in nano- and microscale NMR spectroscopy using diamond quantum sensors.Chemical communications (Cambridge, England) · 2022Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantum metrology enables some of the most precise measurements. In the life sciences, diamond-based quantum sensing has led to a new class of biophysical sensors and diagnostic devices that are being investigated as a platform for cancer screening and ultrasensitive immunoassays. However, a broader application in the life sciences based on nanoscale NMR spectroscopy has been hampered by the need to interface highly sensitive quantum bit (qubit) sensors with their biological targets. Here, we demonstrate an approach that combines quantum engineering with single-molecule biophysics to immobilize individual proteins and DNA molecules on the surface of a bulk diamond crystal that hosts coherent nitrogen vacancy qubit sensors. Our thin (sub-5 nm) functionalization architecture provides precise control over the biomolecule adsorption density and results in near-surface qubit coherence approaching 100 μs. The developed architecture remains chemically stable under physiological conditions for over 5 d, making our technique compatible with most biophysical and biomedical applications.
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