Evidence map›Paper›PMID 35193958›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Multiple genetic paths including massive gene amplification allow

Lin Wang, Emmanuel Asare, Amol C Shetty, Freddy Sanchez-Tumbaco, Megan R Edwards, Rajagopalan Saranathan, Brian Weinrick, Jiayong Xu, Bing Chen, Angèle Bénard and 7 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Transcriptomic and proteomic ramifications of segmental amplification inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. International journal of molecular sciences · 2025
    Review
  9. Article
  10. Pangenome Reconstruction ofMicroorganisms · 2023
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Lin WangCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303.
Emmanuel AsareDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Amol C ShettyInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201.
Freddy Sanchez-TumbacoCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303.
Megan R EdwardsCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303.
Rajagopalan SaranathanDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Brian WeinrickDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0003-0880-4487
Jiayong XuDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Bing ChenDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Angèle BénardWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom.
Gordon DouganWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom.
Daisy W LeungDivision of Infectious Diseases, John T. Milliken Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-7189-9557
Gaya K AmarasingheDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110.
John ChanDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Christopher F BaslerCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303.ORCID 0000-0003-4195-425X
William R JacobsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461; william.jacobs@einsteinmed.edu joann.tufariello@mssm.edu.ORCID 0000-0003-3321-3080
JoAnn M TufarielloCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303; william.jacobs@einsteinmed.edu joann.tufariello@mssm.edu.
Albert Einstein College of Medicine · USGeorgia State University · USWashington University in St. Louis · USWellcome Sanger Institute · GBTrudeau Institute · USUniversity of Maryland, Baltimore · US

Funding

Virology BSL4 CoreP01AI120943 · NIAID · WASHINGTON UNIVERSITY · PI Gaya K. Amarasinghe · 2016 to 2026
$30.2M
Molecular mechanisms of immune dysregulation by filoviral interferon U19AI109945 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BASLER, CHRISTOPHER F · 2014 to 2018
$9.5M
Molecular Genetic Analysis of Mycobacterium TuberculosisR37AI026170 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI WILLIAM Robert JACOBS · 2004 to 2026
$7.7M
MOLECULAR GENETIC ANALYSIS OF MYCOBACTERIUM TUBERCULOSISR01AI026170 · NIAID · YESHIVA UNIVERSITY · PI JACOBS, WILLIAM ROBERT · 1989 to 2022
$7.1M
Immunoregulation by indoleamine 2,3-dioxygenases in tuberculosisR01AI137344 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI CHAN, JOHN R., PORCELLI, STEVEN A · 2018 to 2022
$4.0M
IgM in the regulation of TB immunityR01AI139297 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI CHAN, JOHN R. · 2019 to 2023
$3.6M
NIAID NIH HHS P01 AI120943NIAID NIH HHS R01 AI026170NIAID NIH HHS R01 AI137344NIAID NIH HHS R01 AI139297NIAID NIH HHS R37 AI026170NIAID NIH HHS U19 AI109945
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBacterial Secretion SystemsBiological EvolutionEvolution, MolecularGene AmplificationMiceMycobacterium tuberculosisType VII Secretion SystemsVirulenceVirulence FactorsBacterial Secretion SystemsType VII Secretion SystemsVirulence FactorsESX-3genetic accordionMycobacterium tuberculosisTetR-family transcriptional regulatortype VII secretion system

Identifiers

PMID35193958
PMCPMC8872769
OpenAlexW4213427766

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.