ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Emotion Downregulation Targets Interoceptive Brain Regions While Emotion Upregulation Targets Other Affective Brain Regions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Functional MRI evidence of brain alterations in premenstrual dysphoric disorder: a systematic review.Frontiers in psychiatry · 2026Pooled it
- Increasing coordination and responsivity of emotion-related brain regions with a heart rate variability biofeedback randomized trial.Cognitive, affective & behavioral neuroscience · 2023Trial
- Functional Magnetic Resonance Imaging Correlates of Cognitive Reappraisal of Negative Emotion: A Brain Activation and Generalized Psychophysiological Interaction Study.Brain and behavior · 2026Article
- Distinct Brain Systems Support Afferent and Efferent Autonomic Activity.bioRxiv : the preprint server for biology · 2026Article
- Distinct brain systems support afferent and efferent autonomic activity.Social cognitive and affective neuroscience · 2026Article
- GBV-Net: Hierarchical Fusion of Facial Expressions and Physiological Signals for Multimodal Emotion Recognition.Sensors (Basel, Switzerland) · 2025Article
- It's all connected! Multivariate pattern analysis of inter-network connectivity distinguishes between reappraisal and passive viewing of emotional scenes.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Cerebellar contribution to emotion regulation and its association with medial frontal GABA level.Social cognitive and affective neuroscience · 2025Article
- A Resource-Efficient Multi-Entropy Fusion Method and Its Application for EEG-Based Emotion Recognition.Entropy (Basel, Switzerland) · 2025Article
- Social support and depressive symptoms: the role of childhood maltreatment and brain activity in a moderated mediation model.Social cognitive and affective neuroscience · 2025Article
- Segregation of three resting-state brain networks predicts reappraisal success across the lifespan.Social cognitive and affective neuroscience · 2025Article
- The physiological component of the BOLD signal: Impact of age and heart rate variability biofeedback training.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Decoding acceptance and reappraisal strategies from resting state macro networks.Scientific reports · 2024Article
- The Role of Childhood Trauma in Affective Stress Recovery in Early Psychosis: An Experience Sampling Study.Schizophrenia bulletin · 2024Article
- A systems identification approach using Bayes factors to deconstruct the brain bases of emotion regulation.Nature neuroscience · 2024Article
- Resting heart rate variability is associated with neural adaptation when repeatedly exposed to emotional stimuli.Neuropsychologia · 2024Article
- Association of Cortico-Striatal Engagement During Cue Reactivity, Reappraisal, and Savoring of Drug and Non-Drug Stimuli With Craving in Heroin Addiction.The American journal of psychiatry · 2024Article
- Mind over mood: exploring the executive function's role in downregulation.Frontiers in psychology · 2024Article
- Sex differences in the effects of trait anxiety and age on resting-state functional connectivities of the amygdala.Journal of affective disorders reports · 2023Article
- Sleep-associated insulin resistance promotes neurodegeneration.Molecular biology reports · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Researchers generally agree that when upregulating and downregulating emotion, control regions in the prefrontal cortex turn up or down activity in affect-generating brain areas. However, the "affective dial hypothesis" that turning up and down emotions produces opposite effects in the same affect-generating regions is untested. We tested this hypothesis by examining the overlap between the regions activated during upregulation and those deactivated during downregulation in 54 male and 51 female humans. We found that upregulation and downregulation both recruit regulatory regions, such as the inferior frontal gyrus and dorsal anterior cingulate gyrus, but act on distinct affect-generating regions. Upregulation increased activity in regions associated with emotional experience, such as the amygdala, anterior insula, striatum, and anterior cingulate gyrus as well as in regions associated with sympathetic vascular activity, such as periventricular white matter, while downregulation decreased activity in regions receiving interoceptive input, such as the posterior insula and postcentral gyrus. Nevertheless, participants' subjective sense of emotional intensity was associated with activity in overlapping brain regions (dorsal anterior cingulate, insula, thalamus, and frontal pole) across upregulation and downregulation. These findings indicate that upregulation and downregulation rely on overlapping brain regions to control and assess emotions but target different affect-generating brain regions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.