Evidence map›Paper›PMID 35193860›Full record

ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2022

Antenatal corticosteroid administration and attention-deficit/hyperactivity disorder in childhood: a regression discontinuity study.

Jennifer A Hutcheon, Erin C Strumpf, Jessica Liauw, M Amanda Skoll, Peter Socha, Myriam Srour, Joseph Y Ting, Sam Harper

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jennifer A HutcheonDepartment of Obstetrics & Gynaecology (Hutcheon, Liauw, Skoll), University of British Columbia, Vancouver, BC; Department of Epidemiology, Biostatistics, and Occupational Health (Strumpf, Socha, Harper), Economics (Strumpf), Pediatrics (Srour), and Neurology and Neurosurgery (Srour), McGill University, Montréal, Que.; Department of Pediatrics (Ting), University of British Columbia, Vancouver, BC jhutcheon@bcchr.ca.
Erin C StrumpfDepartment of Obstetrics & Gynaecology (Hutcheon, Liauw, Skoll), University of British Columbia, Vancouver, BC; Department of Epidemiology, Biostatistics, and Occupational Health (Strumpf, Socha, Harper), Economics (Strumpf), Pediatrics (Srour), and Neurology and Neurosurgery (Srour), McGill University, Montréal, Que.; Department of Pediatrics (Ting), University of British Columbia, Vancouver, BC.
Jessica LiauwDepartment of Obstetrics & Gynaecology (Hutcheon, Liauw, Skoll), University of British Columbia, Vancouver, BC; Department of Epidemiology, Biostatistics, and Occupational Health (Strumpf, Socha, Harper), Economics (Strumpf), Pediatrics (Srour), and Neurology and Neurosurgery (Srour), McGill University, Montréal, Que.; Department of Pediatrics (Ting), University of British Columbia, Vancouver, BC.
M Amanda SkollDepartment of Obstetrics & Gynaecology (Hutcheon, Liauw, Skoll), University of British Columbia, Vancouver, BC; Department of Epidemiology, Biostatistics, and Occupational Health (Strumpf, Socha, Harper), Economics (Strumpf), Pediatrics (Srour), and Neurology and Neurosurgery (Srour), McGill University, Montréal, Que.; Department of Pediatrics (Ting), University of British Columbia, Vancouver, BC.
Peter SochaDepartment of Obstetrics & Gynaecology (Hutcheon, Liauw, Skoll), University of British Columbia, Vancouver, BC; Department of Epidemiology, Biostatistics, and Occupational Health (Strumpf, Socha, Harper), Economics (Strumpf), Pediatrics (Srour), and Neurology and Neurosurgery (Srour), McGill University, Montréal, Que.; Department of Pediatrics (Ting), University of British Columbia, Vancouver, BC.
Myriam SrourDepartment of Obstetrics & Gynaecology (Hutcheon, Liauw, Skoll), University of British Columbia, Vancouver, BC; Department of Epidemiology, Biostatistics, and Occupational Health (Strumpf, Socha, Harper), Economics (Strumpf), Pediatrics (Srour), and Neurology and Neurosurgery (Srour), McGill University, Montréal, Que.; Department of Pediatrics (Ting), University of British Columbia, Vancouver, BC.
Joseph Y TingDepartment of Obstetrics & Gynaecology (Hutcheon, Liauw, Skoll), University of British Columbia, Vancouver, BC; Department of Epidemiology, Biostatistics, and Occupational Health (Strumpf, Socha, Harper), Economics (Strumpf), Pediatrics (Srour), and Neurology and Neurosurgery (Srour), McGill University, Montréal, Que.; Department of Pediatrics (Ting), University of British Columbia, Vancouver, BC.
Sam HarperDepartment of Obstetrics & Gynaecology (Hutcheon, Liauw, Skoll), University of British Columbia, Vancouver, BC; Department of Epidemiology, Biostatistics, and Occupational Health (Strumpf, Socha, Harper), Economics (Strumpf), Pediatrics (Srour), and Neurology and Neurosurgery (Srour), McGill University, Montréal, Que.; Department of Pediatrics (Ting), University of British Columbia, Vancouver, BC.
University of British Columbia · CA

Funding

CIHR
6 · The paper itself

Abstract

backgroundAntenatal corticosteroids reduce respiratory morbidity in preterm infants, but their use during late preterm gestation (34-36 weeks) is limited because their safety for longer-term child neurodevelopment is unclear. We sought to determine if fetuses with higher probability of exposure to antenatal corticosteroids had increased rates of prescriptions for attention-deficit/hyperactivity disorder (ADHD) medication in childhood, using a quasiexperimental design that better controls for confounding than existing observational studies.

methodsWe identified 16 358 children whose birthing parents were admitted for delivery between 31 + 0 (31 weeks, 0 days) and 36 + 6 weeks' gestation in 2000-2013, using a perinatal data registry from British Columbia, Canada, and linked their records with population-based child ADHD medication data (2000-2018). We used a regression discontinuity design to capitalize on the fact that pregnancies presenting for delivery immediately before and immediately after the clinical cut-off for antenatal corticosteroid administration of 34 + 0 weeks' gestation have very different levels of exposure to corticosteroids, but are otherwise similar with respect to confounders.

resultsOver a median follow-up period of 9 years, 892 (5.5%) children had 1 or more dispensations of ADHD medication. Children whose birthing parents were admitted for delivery just before the corticosteroid clinical cut-off of 34 + 0 weeks' gestation did not appear to be more likely to be prescribed ADHD medication than those admitted just after the cut-off (rate ratio 1.1, 95% confidence interval [CI] 0.8 to 1.6; 1.3 excess cases per 100 children, 95% CI -2.5 to 5.7).

interpretationWe found little evidence that children with higher probability of exposure to antenatal corticosteroids have higher rates of ADHD prescriptions in childhood, supporting the safety of antenatal corticosteroids for this neurodevelopmental outcome.

Indexed as

Prenatal Exposure Delayed EffectsAdrenal Cortex HormonesAttention Deficit Disorder with HyperactivityChildFemaleFollow-Up StudiesHumansInfant, NewbornPregnancyPregnancy Trimester, ThirdPrenatal CareRegression AnalysisRespiratory Distress Syndrome, NewbornAdrenal Cortex Hormones

Identifiers

PMID35193860
PMCPMC8863198
OpenAlexW4212894691

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.