Evidence map›Paper›PMID 35193856›Full record

ReviewBritish journal of sports medicine2022

Exercise-induced laryngeal obstruction (EILO) in athletes: a narrative review by a subgroup of the IOC Consensus on 'acute respiratory illness in the athlete'.

Hege Havstad Clemm, J Tod Olin, Cameron McIntosh, Martin Schwellnus, Nicola Sewry, James H Hull, Thomas Halvorsen

Open access · hybridAbstract readReview
In one paragraph

Review in British journal of sports medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Guideline
  2. Exercise and the lungs: From physiology to pathophysiology - a narrative review.African journal of thoracic and critical care medicine · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Clinical Case Study: Pediatric Exercise-Induced Laryngeal Obstruction.Perspectives of the ASHA special interest groups · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Hege Havstad ClemmDepartment of Pediatric and Adolescent Medicine, Haukeland Universityhospital, Bergen, Norway hsyh@helse-bergen.no.ORCID http://orcid.org/0000-0002-0096-4032
J Tod OlinDepartment of Pediatrics and Medicine, National Jewish Health, Denver, Colorado, USA.ORCID http://orcid.org/0000-0003-0521-7623
Cameron McIntoshEdge Day Hospital, Port Elizabeth, South Africa.
Martin SchwellnusSport, Exercise Medicine and Lifestyle Institute (SEMLI), Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Nicola SewrySport, Exercise Medicine and Lifestyle Institute (SEMLI), Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
James H HullDepartment of Respiratory Medicine, Royal Brompton and Harefield NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0003-4697-1526
Thomas HalvorsenDepartment of Pediatric and Adolescent Medicine, Haukeland Universityhospital, Bergen, Norway.ORCID http://orcid.org/0000-0003-1471-0225
Haukeland University Hospital · NOSetshaba Research Centre · ZANational Jewish Health · USRoyal Brompton & Harefield NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise-induced laryngeal obstruction (EILO) is caused by paradoxical inspiratory adduction of laryngeal structures during exercise. EILO is an important cause of upper airway dysfunction in young individuals and athletes, can impair exercise performance and mimic lower airway dysfunction, such as asthma and/or exercise-induced bronchoconstriction. Over the past two decades, there has been considerable progress in the recognition and assessment of EILO in sports medicine. EILO is a highly prevalent cause of unexplained dyspnoea and wheeze in athletes. The preferred diagnostic approach is continuous visualisation of the larynx (via laryngoscopy) during high-intensity exercise. Recent data suggest that EILO consists of different subtypes, possibly caused via different mechanisms. Several therapeutic interventions for EILO are now in widespread use, but to date, no randomised clinical trials have been performed to assess their efficacy or inform robust management strategies. The aim of this review is to provide a state-of-the-art overview of EILO and guidance for clinicians evaluating and treating suspected cases of EILO in athletes. Specifically, this review examines the pathophysiology of EILO, outlines a diagnostic approach and presents current therapeutic algorithms. The key unmet needs and future priorities for research in this area are also covered.

Indexed as

Airway ObstructionAsthma, Exercise-InducedLaryngeal DiseasesAthletesHumansLaryngoscopyPractice Guidelines as Topicasthmaathletesexerciserespiratory systemsports medicine

Identifiers

PMID35193856
PMCPMC9120388
OpenAlexW4213426709

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.