ArticleAnimal microbiome2022
Glyphosate induces immune dysregulation in honey bees.
Article in Animal microbiome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- A network-based meta-analysis of the honeybee gut microbiome: geographic, seasonal, and pesticide-associated shifts.Scientific reports · 2026Pooled it
- Presence of Emerging Contaminants in UK Honey─Human Pharmaceuticals a Concern for Honeybees?Journal of agricultural and food chemistry · 2026Article
- Mycotoxins as an Underestimated Honeybee Stressor: Aflatoxin, Contaminated Pollen, and Colony-Level Risk.Biology · 2026Review
- Article
- How Glyphosate and Its Derivatives Influence Antimicrobial Resistance Emergence and Transmission: A One Health Perspective.Antibiotics (Basel, Switzerland) · 2026Review
- Evaluation of the Health Status ofToxics · 2026Article
- Melatonin as a Potential Dietary Supplement to Counteract Glyphosate-Induced Decline in Honeybee Populations.Insects · 2026Article
- Common herbicide impairs fertility but not survival in bumblebees, Bombus impatiens.Scientific reports · 2025Article
- One Health, One Microbiome.Microbiome · 2025Review
- Interactions of husbandry, landscape, and immunity in regulating viral loads for managed honey bees.Biology open · 2025Article
- Toxicological concerns regarding glyphosate, its formulations, and co-formulants as environmental pollutants: a review of published studies from 2010 to 2025.Archives of toxicology · 2025Review
- Glyphosate-Based Herbicides and Their Potential Impact on the Microbiota of Social Bees.Toxics · 2025Review
- Insect immunity in the Anthropocene.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Semi-field studies on biochemical markers of honey bee workers (Apis mellifera) after exposure to pesticides and their mixtures.PloS one · 2025Article
- Combined Toxic Effects of Lead and Glyphosate onInsects · 2024Article
- Current Insights into Sublethal Effects of Pesticides on Insects.International journal of molecular sciences · 2024Review
- The honeybee microbiota and its impact on health and disease.Nature reviews. Microbiology · 2024Review
- Bees on the run:Frontiers in veterinary science · 2024Article
- Article
- Glyphosate and a glyphosate-based herbicide affect bumblebee gut microbiota.FEMS microbiology ecology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSimilar to many other animals, the honey bee Apis mellifera relies on a beneficial gut microbiota for regulation of immune homeostasis. Honey bees exposed to agrochemicals, such as the herbicide glyphosate or antibiotics, usually exhibit dysbiosis and increased susceptibility to bacterial infection. Considering the relevance of the microbiota-immunity axis for host health, we hypothesized that glyphosate exposure could potentially affect other components of the honey bee physiology, such as the immune system.
resultsIn this study, we investigated whether glyphosate, besides affecting the gut microbiota, could compromise two components of honey bee innate immunity: the expression of genes encoding antimicrobial peptides (humoral immunity) and the melanization pathway (cellular immunity). We also compared the effects of glyphosate on the bee immune system with those of tylosin, an antibiotic commonly used in beekeeping. We found that both glyphosate and tylosin decreased the expression of some antimicrobial peptides, such as apidaecin, defensin and hymenoptaecin, in exposed honey bees, but only glyphosate was able to inhibit melanization in the bee hemolymph.
conclusionsExposure of honey bees to glyphosate or tylosin can reduce the abundance of beneficial gut bacteria and lead to immune dysregulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.