Evidence map›Paper›PMID 35193694›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2022

Introduction and expression of PIK3CA

Nicole Pinto, Kara M Ruicci, Mohammed Imran Khan, Mushfiq Hassan Shaikh, Yu Fan Peter Zeng, John Yoo, Kevin Fung, S Danielle MacNeil, Adrian Mendez, Joe S Mymryk and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Nicole PintoDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.
Kara M RuicciDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.
Mohammed Imran KhanDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.
Mushfiq Hassan ShaikhDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.
Yu Fan Peter ZengDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.
John YooDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.
Kevin FungDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.
S Danielle MacNeilDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.
Adrian MendezDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.
Joe S MymrykDepartment of Oncology, Western University, London, ON, Canada.
John W BarrettDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0003-3708-3834
Paul C BoutrosEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, USA.
Anthony C NicholsDepartment of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada. anthony.nichols@lhsc.on.ca.
Western University · CAUniversity of California, Los Angeles · US

Funding

Institute of Cancer Research MOP377832
6 · The paper itself

Abstract

Anaplastic thyroid cancer (ATC) is a rare, aggressive form of undifferentiated thyroid cancer, which exhibits rapid progression and is almost universally fatal. At least a subset of ATC is thought to arise from pre-existing well-differentiated thyroid cancer, most frequently papillary thyroid cancer (PTC). While PIK3CA mutations are rare in PTC, they are common in ATC and tend to co-occur with BRAF mutations. This provided the rationale for our study to identify the potential role of PIK3CA mutations in the progression from well-differentiated to undifferentiated thyroid cancer. We introduced PIK3CA

Indexed as

Class I Phosphatidylinositol 3-KinasesProto-Oncogene Proteins B-rafThyroid NeoplasmsAnimalsCell LineCell Line, TumorHumansMiceMice, NudeMutationPhenotypeThyroid Cancer, PapillaryClass I Phosphatidylinositol 3-KinasesPIK3CA protein, humanProto-Oncogene Proteins B-rafAnaplastic thyroid cancerDedifferentiationDisease progressionPapillary thyroid cancer

Identifiers

PMID35193694
PMCPMC8862267
OpenAlexW4213248386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.