Evidence map›Paper›PMID 35193628›Full record

ReviewChinese medicine2022

Key quality factors for Chinese herbal medicines entering the EU market.

Mei Wang, Pei-Fen Yao, Peng-Yue Sun, Wen Liang, Xiao-Jia Chen

Abstract readReview
In one paragraph

Review in Chinese medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Heavy metals and pesticides in medicinal plants: environmental sources, plant responses, and human health risk assessment.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mei Wang *LU-European Center for Chinese Medicine and Natural Compounds, Institute of Biology, Leiden University, Sylviusweg72, 2333BE, Leiden, The Netherlands. Mei.Wang@Subiomedicine.com.
Pei-Fen Yao *Institute of Chinese Medical Sciences, and State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Avenida da Universidade, Taipa, Macao SAR, People's Republic of China.
Peng-Yue SunSU Biomedicine, BioPartner Center 3, Galileiweg 8, Leiden Bio Science Park, 2333 BD, Leiden, the Netherlands.
Wen LiangSU Biomedicine, BioPartner Center 3, Galileiweg 8, Leiden Bio Science Park, 2333 BD, Leiden, the Netherlands.
Xiao-Jia ChenInstitute of Chinese Medical Sciences, and State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Avenida da Universidade, Taipa, Macao SAR, People's Republic of China. XiaojiaChen@um.edu.mo.ORCID http://orcid.org/0000-0001-5872-5790

Funding

Dutch Provincie Noord_Holland MIT grant 1275358/1326082Guangxi Science and Technology Research Project GuiKe AA18242040National Natural Science Foundation of China 82104354The Science and Technology Development Fund, Macau SAR 0016/2021/AUniversidade de Macau MYRG2018-00207-ICMSUniversidade de Macau MYRG2019-00121-ICMS
6 · The paper itself

Abstract

Chinese herbal medicines (CHMs) have unique advantages in the prevention and treatment of diseases, which are widely recognized in the world. More and more CHMs are becoming increasingly popular in the international markets. However, the quality control of CHMs is a significant issue for their acceptance and recognition in the international market. This review mainly focuses on the quality requirements for CHMs to enter the European Union (EU) market. Both Chinese and European regulations and quality controls are compared. Firstly, the EU medicinal regulatory system and relevant regulations were reviewed. Secondly, the key factors of the quality control of CHMs, including Chinese herbal drugs, extracts and products were compared with those of European herbal medicines in the EU market. Subsequently, three main registration routes for herbal medicinal products including Chinese herbal medicinal products entering the EU were introduced. Furthermore, the legal status of traditional Chinese medicine granules in the EU was also discussed. Through the comparison of the key quality factors for CHMs in China and the EU, the similarities and differences in terms of quality requirements and regulations are addressed, which provides a reference for the development of CHMs into the EU market.

Indexed as

Chinese herbal medicinesChinese PharmacopoeiaEuropean herbal medicine legislationEuropean marketEuropean PharmacopoeiaQuality requirements

Identifiers

PMID35193628
PMCPMC8861989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.