Evidence map›Paper›PMID 35193608›Full record

Trial reportMalaria journal2022

Impact of seasonal RTS,S/AS01

Jane Grant, Issaka Sagara, Issaka Zongo, Matthew Cairns, Rakiswendé Serge Yerbanga, Modibo Diarra, Charles Zoungrana, Djibrilla Issiaka, Frédéric Nikièma, Frédéric Sompougdou and 19 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Malaria journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03143218 (A Phase IIIB Comparative Trial of Seasonal Vaccination With the Malaria Vaccine RTS,S/AS01, Seasonal Malaria Chemoprevention and of the Two Interventions Combined), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03143218 phase3completednot on this map

A Phase IIIB Comparative Trial of Seasonal Vaccination With the Malaria Vaccine RTS,S/AS01, Seasonal Malaria Chemoprevention and of the Two Interventions Combined

TypeinterventionalSponsorLondon School of Hygiene and Tropical MedicineRan2017 to 2020Enrolled5,920ConditionsMalaria,Falciparum, Children, OnlyArmsRABIPUR®, RTS,S/AS01, SMC with SP+AQ, SMC placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 5 institutions in 5 countries.

Jane GrantLondon School of Hygiene and Tropical Medicine, Keppel St., London, WC1E 7HT, UK. jane.grant2@lshtm.ac.uk.ORCID http://orcid.org/0000-0002-1607-4042
Issaka SagaraMalaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako, Mali.
Issaka ZongoInstitut de Recherche en Sciences de La Santé, Bobo-Dioulasso, Burkina Faso.
Matthew CairnsLondon School of Hygiene and Tropical Medicine, Keppel St., London, WC1E 7HT, UK.
Rakiswendé Serge YerbangaInstitut de Recherche en Sciences de La Santé, Bobo-Dioulasso, Burkina Faso.
Modibo DiarraMalaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako, Mali.
Charles ZoungranaInstitut de Recherche en Sciences de La Santé, Bobo-Dioulasso, Burkina Faso.
Djibrilla IssiakaMalaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako, Mali.
Frédéric NikièmaInstitut de Recherche en Sciences de La Santé, Bobo-Dioulasso, Burkina Faso.
Frédéric SompougdouInstitut de Recherche en Sciences de La Santé, Bobo-Dioulasso, Burkina Faso.
Amadou TapilyMalaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako, Mali.
Mahamadou KayaMalaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako, Mali.
Alassane HaroInstitut de Recherche en Sciences de La Santé, Bobo-Dioulasso, Burkina Faso.
Koualy SanogoMalaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako, Mali.
Abdoul Aziz SienouInstitut de Recherche en Sciences de La Santé, Bobo-Dioulasso, Burkina Faso.
Seydou TraoreMalaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako, Mali.
Ismaila TheraMalaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako, Mali.
Hama YalcouyeMalaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako, Mali.
Irene KuepferLondon School of Hygiene and Tropical Medicine, Keppel St., London, WC1E 7HT, UK.
Paul SnellLondon School of Hygiene and Tropical Medicine, Keppel St., London, WC1E 7HT, UK.
Paul MilliganLondon School of Hygiene and Tropical Medicine, Keppel St., London, WC1E 7HT, UK.
Christian OckenhousePATH, Seattle, USA.
Opokua Ofori-AnyinamGlaxoSmithKline Vaccines, Rixensart, Belgium.
Halidou TintoInstitut de Recherche en Sciences de La Santé, Bobo-Dioulasso, Burkina Faso.
Abdoulaye DjimdeMalaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako, Mali.
Daniel ChandramohanLondon School of Hygiene and Tropical Medicine, Keppel St., London, WC1E 7HT, UK.
Brian GreenwoodLondon School of Hygiene and Tropical Medicine, Keppel St., London, WC1E 7HT, UK.
Alassane DickoMalaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako, Mali.
Jean-Bosco OuédraogoInstitut de Recherche en Sciences de La Santé, Bobo-Dioulasso, Burkina Faso.
Université des Sciences, des Techniques et des Technologies de Bamako · MLInstitut de Recherche en Sciences de la Santé · BFUniversity of London · GBGlaxoSmithKline (Belgium) · BEProgram for Appropriate Technology in Health · US

Funding

Medical Research Council MR/P006876/1Medical Research Council MR/R010161/1PATH 18269United Kingdom Joint Global Health Trials MR/P006876/1
6 · The paper itself

Abstract

backgroundA recent trial in Burkina Faso and Mali showed that combining seasonal RTS,S/AS01

methodsIn Burkina Faso and Mali 5920 children were randomized to receive either SMC alone, RTS,S/AS01

resultsIn 2017, compared to SMC alone, the combined intervention reduced the prevalence of wasting by approximately 12% [prevalence ratio (PR) = 0.88 (95% CI 0.75, 1.03)], and approximately 21% in 2018 [PR = 0.79 (95% CI 0.62, 1.01)]. Point estimates were similar for comparisons with RTS,S/AS01

conclusionsDespite a high burden of malnutrition and malaria in the study populations, and a major reduction in the incidence of malaria in children receiving both interventions, this had only a modest impact on nutritional status. Therefore, other interventions are needed to reduce the high burden of malnutrition in these areas.

trial registrationhttps://www.clinicaltrials.gov/ct2/show/NCT03143218 , registered 8th May 2017.

Indexed as

AntimalarialsMalariaBurkina FasoChemopreventionChildChild, PreschoolCross-Sectional StudiesHumansInfantMaliNutritional StatusSeasonsVaccinationAntimalarialsBurkina FasoMalariaMaliNutritionRTS,S/AS01ESeasonal malaria chemoprevention

Identifiers

PMID35193608
PMCPMC8864823
OpenAlexW4212909517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.