Evidence map›Paper›PMID 35193574›Full record

ArticleBMC medicine2022

Long COVID 12 months after discharge: persistent symptoms in patients hospitalised due to COVID-19 and patients hospitalised due to other causes-a multicentre cohort study.

Mario Rivera-Izquierdo, Antonio Jesús Láinez-Ramos-Bossini, Inmaculada Guerrero-Fernández de Alba, Rocío Ortiz-González-Serna, Álvaro Serrano-Ortiz, Nicolás Francisco Fernández-Martínez, Rafael Ruiz-Montero, Jorge A Cervilla

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 9 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 9 syntheses or guidelines pooled it, 65 citations in OpenAlex.

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  8. Comparison of Long COVID-19 Caused by Different SARS-CoV-2 Strains: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
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  17. COVID-19 and Mental Health: A "Pandemic Within a Pandemic".Advances in experimental medicine and biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Mario Rivera-IzquierdoDepartment of Preventive Medicine and Public Health, University of Granada, Avenida de la Investigación 11, 18016, Granada, Spain. mariorivera@ugr.es.ORCID 0000-0001-6159-6037
Antonio Jesús Láinez-Ramos-BossiniService of Radiology, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Inmaculada Guerrero-Fernández de AlbaService of Preventive Medicine and Public Health, Hospital Universitario San Cecilio, Granada, Spain.
Rocío Ortiz-González-SernaService of Preventive Medicine and Public Health, Hospital Universitario Reina Sofía, Córdoba, Spain.
Álvaro Serrano-OrtizService of Preventive Medicine and Public Health, Hospital Universitario Reina Sofía, Córdoba, Spain.
Nicolás Francisco Fernández-MartínezService of Preventive Medicine and Public Health, Hospital Universitario Reina Sofía, Córdoba, Spain.
Rafael Ruiz-MonteroService of Preventive Medicine and Public Health, Hospital Universitario Reina Sofía, Córdoba, Spain.
Jorge A CervillaDepartment of Psychiatry, University of Granada, Granada, Spain.
Instituto Maimónides de Investigación Biomédica de Córdoba · ESUniversidad de Granada · ESHospital Universitario Virgen de las Nieves · ESInstituto de Investigación Biosanitaria de Granada · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong-term-specific sequelae or persistent symptoms (SPS) after hospitalisation due to COVID-19 are not known. The aim of this study was to explore the presence of SPS 12 months after discharge in survivors hospitalised due to COVID-19 and compare it with survivors hospitalised due to other causes.

methodsProspective cohort study, the Andalusian Cohort of Hospitalised patients for COVID-19 (ANCOHVID study), conducted in 4 hospitals and 29 primary care centres in Andalusia, Spain. The sample was composed of 906 adult patients; 453 patients hospitalised due to COVID-19 (exposed) and 453 hospitalised due to other causes (non-exposed) from March 1 to April 15, 2020, and discharged alive. The main outcomes were (1) the prevalence of SPS at 12 months after discharge and (2) the incidence of SPS after discharge. Outcome data at 12 months were compared between the exposed and non-exposed cohorts. Risk ratios were calculated, and bivariate analyses were performed.

resultsA total of 163 (36.1%) and 160 (35.3%) patients of the exposed and non-exposed cohorts, respectively, showed at least one SPS at 12 months after discharge. The SPS with higher prevalence in the subgroup of patients hospitalised due to COVID-19 12 months after discharge were persistent pharyngeal symptoms (p<0.001), neurological SPS (p=0.049), confusion or memory loss (p=0.043), thrombotic events (p=0.025) and anxiety (p=0.046). The incidence of SPS was higher for the exposed cohort regarding pharyngeal symptoms (risk ratio, 8.00; 95% CI, 1.85 to 36.12), confusion or memory loss (risk ratio, 3.50; 95% CI, 1.16 to 10.55) and anxiety symptoms (risk ratio, 2.36; 95% CI, 1.28 to 4.34).

conclusionsThere was a similar frequency of long-term SPS after discharge at 12 months, regardless of the cause of admission (COVID-19 or other causes). Nevertheless, some symptoms that were found to be more associated with COVID-19, such as memory loss or anxiety, merit further investigation. These results should guide future follow-up of COVID-19 patients after hospital discharge.

Indexed as

COVID-19AdultCohort StudiesHospitalizationHumansPatient DischargePost-Acute COVID-19 SyndromeProspective StudiesSARS-CoV-2Cohort studyFollow-upLong termPersistent COVID-19Sequelae

Identifiers

PMID35193574
PMCPMC8863509
OpenAlexW4213428993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.