Evidence map›Paper›PMID 35193549›Full record

ReviewBMC ophthalmology2022

The role of lipopolysaccharides in diabetic retinopathy.

Xinran Qin, Haidong Zou

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Xinran QinDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Haidong ZouDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zouhaidong@sjtu.edu.cn.
Shanghai First People's Hospital · CNShanghai Jiao Tong University · CN

Funding

National Natural Science Foundation of China 82071012Science and Technology Commission of Shanghai Municipality 20DZ1100200Shanghai engineering research center of precise diagnosis and treatment of eye diseases, Shanghai, China 19DZ2250100Shanghai General Hospital, Clinical Research CTCCR-2018Z01Shanghai public health system three-year plan-Key Subjects GWV10.1-XK7Shanghai Shen Kang Hospital Development Center SHDC2018110Shanghai Shen Kang Hospital Development Center SHDC2020CR30538
6 · The paper itself

Abstract

Diabetes mellitus (DM) is a complex metabolic syndrome characterized by hyperglycemia. Diabetic retinopathy (DR) is the most common complication of DM and the leading cause of blindness in the working-age population of the Western world. Lipopolysaccharides (LPS) is an essential ingredient of the outer membrane of gram-negative bacteria, which induces systemic inflammatory responses and cellular apoptotic changes in the host. High-level serum LPS has been found in diabetic patients at the advanced stages, which is mainly due to gut leakage and dysbiosis. In this light, increasing evidence points to a strong correlation between systemic LPS challenge and the progression of DR. Although the underlying molecular mechanisms have not been fully elucidated yet, LPS-related pathobiological events in the retina may contribute to the exacerbation of vasculopathy and neurodegeneration in DR. In this review, we focus on the involvement of LPS in the progression of DR, with emphasis on the blood-retina barrier dysfunction and dysregulated glial activation. Eventually, we summarize the recent advances in the therapeutic strategies for antagonising LPS activity, which may be introduced to DR treatment with promising clinical value.

Indexed as

Diabetes MellitusDiabetic RetinopathyBlood-Retinal BarrierHumansLipopolysaccharidesRetinaLipopolysaccharidesBlood-retina barrierDiabetic retinopathyDysbiosisGut leakageInflammationLipopolysaccharidesRetinal glia

Identifiers

PMID35193549
PMCPMC8862382
OpenAlexW4212778254

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.