Evidence map›Paper›PMID 35193538›Full record

ArticleBMC psychiatry2022

Data-driven study on resting-state functional magnetic resonance imaging during early abstinence of alcohol dependence in male patients and its predictive value for relapse.

Renhao Deng, Xia Yang, Ya-Jing Meng, Yu-Jie Tao, Hui-Yao Wang, Xiao-Jing Li, Wei Wei, Hua Yu, Qiang Wang, Wei Deng and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Prediction of alcohol intake patterns with olfactory and gustatory brain connectivity networks.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Renhao Deng *Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Xia Yang *Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Ya-Jing MengMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Yu-Jie TaoMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Hui-Yao WangMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Xiao-Jing LiMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Wei WeiMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Hua YuMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Qiang WangMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Wei DengMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Lian-Sheng ZhaoMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Xiao-Hong MaMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Ming-Li LiMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Jia-Jun XuMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Jing LiMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Yan-Song LiuDepartment of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhen TangDepartment of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China.
Xiang-Dong DuDepartment of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China.
Jeremy W CoidMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Andrew J GreenshawDepartment of Psychiatry, University of Alberta, Edmonton, Canada.
Tao LiMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China.
Wan-Jun GuoMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Chengdu, 610041, Sichuan, China. guowjcn@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlcohol dependence is a mental disorder with a high relapse rate. However, specific neuroimaging biomarkers have not been determined for alcohol dependence and its relapse. We conducted data-driven research to investigate resting-state functional magnetic resonance imaging (rs-fMRI) during early abstinence from alcohol dependence and its potential ability to predict relapse.

methodsParticipants included 68 alcohol-dependent patients and 68 healthy controls (HCs). The regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFF) were compared between the alcohol dependence group and the HCs and between the relapse group and the nonrelapse group. The brain regions that presented significantly different ReHo and/or fALFF between the alcohol-dependent patients and HCs and/or between the relapsed and nonrelapsed patients were selected as the seeds to calculate the functional connectivities (FCs).

resultsDuring a 6-month follow-up period, 52.24% of alcohol-dependent patients relapsed. A regression model for differentiating alcohol-dependent patients and HCs showed that reductions in ReHo in the left postcentral region, fALFF in the right fusiform region, and FC in the right fusiform region to the right middle cingulum were independently associated with alcohol dependence, with an area under the receiver operating characteristic curve (AUC) of 0.841. The baseline FC of the left precentral to the left cerebellum of the relapse group was significantly lower than that of the nonrelapse group. The AUC of this FC to predict relapse was 0.774.

conclusionsOur findings contribute to advancing research on the neurobiological etiology and predictive biomarkers for relapse associated with alcohol dependence.

Indexed as

AlcoholismBrainBrain MappingHumansMagnetic Resonance ImagingMaleRecurrenceAlcohol dependenceMagnetic resonance imagingPredictorRelapse

Identifiers

PMID35193538
PMCPMC8862392

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.