Evidence map›Paper›PMID 35193484›Full record

ReviewCurrent neuropharmacology2022

Neonatal Arterial Ischaemic Stroke: Advances in Pathologic Neural Death, Diagnosis, Treatment, and Prognosis.

Yang He, Junjie Ying, Jun Tang, Ruixi Zhou, Haibo Qu, Yi Qu, Dezhi Mu

Open access · greenAbstract readReview
In one paragraph

Review in Current neuropharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yang HeDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Junjie YingDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Jun TangDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Ruixi ZhouDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Haibo QuDepartment of Radiology, West China Second University Hospital, Sichuan University, Chengdu, China.
Yi QuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Dezhi MuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
West China Second University Hospital of Sichuan University · CNSichuan University · CN

Funding

Fundamental Research Funds for the Central University SCU2021D009National Key Project of Neonatal Children 1311200003303National Key R&D Program of China 2021YFC2701700, 2017YFA0104200National Natural Science Foundation of China 82171710, 81971433, 81771634, 81971428, 81630038Science and Technology Bureau of Sichuan Province 2021YJ0017, 2020YFS0041, 2020YJ0236
6 · The paper itself

Abstract

Neonatal arterial ischaemic stroke (NAIS) is caused by focal arterial occlusion and often leads to severe neurological sequelae. Neural deaths after NAIS mainly include necrosis, apoptosis, necroptosis, autophagy, ferroptosis, and pyroptosis. These neural deaths are mainly caused by upstream stimulations, including excitotoxicity, oxidative stress, inflammation, and death receptor pathways. The current clinical approaches to managing NAIS mainly focus on supportive treatments, including seizure control and anticoagulation. In recent years, research on the pathology, early diagnosis, and potential therapeutic targets of NAIS has progressed. In this review, we summarise the latest progress of research on the pathology, diagnosis, treatment, and prognosis of NAIS and highlight newly potential diagnostic and treatment approaches.

Indexed as

Brain IschemiaIschemic StrokeStrokeHumansInfant, NewbornPrognosisSeizuresdiagnosisNAISpathologyprognosistherapeutic targets.treatment

Identifiers

PMID35193484
PMCPMC9890291
OpenAlexW4213445498

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.