ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2024
Neurobehavioral and Clinical Comorbidities in Epilepsy: The Role of White Matter Network Disruption.
Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Etiology-specific trajectories of longitudinal functional connectivity and network topology in posttraumatic and mesial temporal lobe epileptogenesis.Experimental neurology · 2026Article
- Network-based biomarkers in pediatric drug-resistant epilepsy.Clinical and experimental pediatrics · 2026Article
- Classification of neurocognitive impairment in pediatric drug-resistant focal epilepsy by quantifying seizure-affected brain network abnormalities in clinical diffusion-weighted imaging connectome.Clinical and experimental pediatrics · 2026Article
- The network neuropsychology of neighborhood deprivation in juvenile myoclonic epilepsy.Scientific reports · 2026Article
- The role of social context in cognitive and neurobehavioural outcomes in epilepsy.Nature reviews. Neurology · 2026Review
- Article
- Cognitive and brain health in juvenile myoclonic epilepsy: Role of social determinants of health.Epilepsia · 2025Article
- The causal relationship of DTI phenotypes and epilepsy: A two sample mendelian randomization study.Epilepsia open · 2024Article
- Comparison of different group-level templates in gradient-based multimodal connectivity analysis.Network neuroscience (Cambridge, Mass.) · 2024Article
- Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice.Frontiers in pharmacology · 2024Article
- Preoperative white matter network organization and memory decline after epilepsy surgery.Journal of neurosurgery · 2023Article
- Multi-shell connectome DWI-based graph theory measures for the prediction of temporal lobe epilepsy and cognition.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Bilingualism and Structural Network Organization in Temporal Lobe Epilepsy: Resilience in Neurologic Disease.Neurology · 2023Observational
- Application of data harmonization and tract-based spatial statistics reveals white matter structural abnormalities in pediatric patients with focal cortical dysplasia.Epilepsy & behavior : E&B · 2023Article
- Article
- The presence, nature and network characteristics of behavioural phenotypes in temporal lobe epilepsy.Brain communications · 2023Article
- Brain diffusion tensor imaging reveals altered connections and networks in epilepsy patients.Frontiers in human neuroscience · 2023Article
- Spatial patterns of gray and white matter compromise relate to age of seizure onset in temporal lobe epilepsy.NeuroImage. Clinical · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Epilepsy is a common neurological disorder associated with alterations in cortical and subcortical brain networks. Despite a historical focus on gray matter regions involved in seizure generation and propagation, the role of white matter (WM) network disruption in epilepsy and its comorbidities has sparked recent attention. In this review, we describe patterns of WM alterations observed in focal and generalized epilepsy syndromes and highlight studies linking WM disruption to cognitive and psychiatric comorbidities, drug resistance, and poor surgical outcomes. Both tract-based and connectome-based approaches implicate the importance of extratemporal and temporo-limbic WM disconnection across a range of comorbidities, and an evolving literature reveals the utility of WM patterns for predicting outcomes following epilepsy surgery. We encourage new research employing advanced analytic techniques (e.g., machine learning) that will further shape our understanding of epilepsy as a network disorder and guide individualized treatment decisions. We also address the need for research that examines how neuromodulation and other treatments (e.g., laser ablation) affect WM networks, as well as research that leverages larger and more diverse samples, longitudinal designs, and improved magnetic resonance imaging acquisitions. These steps will be critical to ensuring generalizability of current research and determining the extent to which neuroplasticity within WM networks can influence patient outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.