Evidence map›Paper›PMID 35193398›Full record

ArticleProceedings. Biological sciences2022

Cellular and immunological mechanisms influence host-adapted phenotypes in a vector-borne microparasite.

Yi-Pin Lin, Danielle M Tufts, Matthew Combs, Alan P Dupuis, Ashley L Marcinkiewicz, Andrew D Hirsbrunner, Alexander J Diaz, Jessica L Stout, Anna M Blom, Klemen Strle and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings. Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. DifferentiatingInfection and immunity · 2025
    Article
  4. Article
  5. Hitchhiker's Guide toJournal of bacteriology · 2024
    Review
  6. Comparative reservoir competence ofApplied and environmental microbiology · 2024
    Article
  7. Review
  8. Differential Resistance ofPathogens (Basel, Switzerland) · 2023
    Article
  9. Article
  10. Structural evolution of an immune evasion determinant shapes pathogen host tropism.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. White-Tailed Deer Serum Kills the Lyme Disease Spirochete,Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2023
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Yi-Pin LinDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA.ORCID 0000-0002-5240-2031
Danielle M TuftsDepartment of Ecology, Evolution, and Environmental Biology, Columbia University, New York, NY, USA.ORCID 0000-0002-8084-7556
Matthew CombsDepartment of Ecology, Evolution, and Environmental Biology, Columbia University, New York, NY, USA.
Alan P DupuisDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA.
Ashley L MarcinkiewiczDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA.
Andrew D HirsbrunnerDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA.
Alexander J DiazDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA.
Jessica L StoutDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA.
Anna M BlomDivision of Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmo, Sweden.
Klemen StrleDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA.
April D DavisDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA.
Laura D KramerDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA.
Sergios-Orestis KolokotronisDepartment of Epidemiology and Biostatistics, School of Public Health, College of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Maria A Diuk-WasserDepartment of Ecology, Evolution, and Environmental Biology, Columbia University, New York, NY, USA.ORCID 0000-0001-8809-3050
New York State Department of Health · USColumbia University · USLund University · SESUNY Downstate Health Sciences University · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Predicting pathogen emergence and spillover risk requires understanding the determinants of a pathogens' host range and the traits involved in host competence. While host competence is often considered a fixed species-specific trait, it may be variable if pathogens diversify across hosts. Balancing selection can lead to maintenance of pathogen polymorphisms (multiple-niche-polymorphism; MNP). The causative agent of Lyme disease,

Indexed as

Borrelia burgdorferiBorrelia burgdorferi GroupLyme DiseaseAnimalsHost AdaptationPeromyscusPhenotypeAmerican robinBorreliahost adaptationLyme diseasewhite-footed mouse

Identifiers

PMID35193398
PMCPMC8864362
OpenAlexW4213426496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.