Evidence map›Paper›PMID 35193388›Full record

ArticleJournal of the Royal Society, Interface2022

Biocompatible, photo-responsive layer-by-layer polymer nanocapsules with an oil core:

Chiara Di Cicco, Raffaele Vecchione, Vincenzo Quagliariello, Alice Busato, Immacolata Tufano, Emiliano Bedini, Marco Gerosa, Andrea Sbarbati, Federico Boschi, Pasquina Marzola and 2 more

Abstract read
In one paragraph

Article in Journal of the Royal Society, Interface, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chiara Di CiccoCenter for Advanced Biomaterials for Healthcare@CRIB, Istituto Italiano di Tecnologia (IIT), Largo Barsanti e Matteucci 53, 80125 Naples, Italy.ORCID 0000-0002-8246-521X
Raffaele VecchioneCenter for Advanced Biomaterials for Healthcare@CRIB, Istituto Italiano di Tecnologia (IIT), Largo Barsanti e Matteucci 53, 80125 Naples, Italy.ORCID 0000-0002-8831-7891
Vincenzo QuagliarielloDivision of Cardiology, Istituto Nazionale Tumori- IRCCS- Fondazione G. Pascale, Via Mariano Semmola 53, 80131 Naples, Italy.
Alice BusatoDepartment of Computer Science Research Area in Experimental and Applied Physics, University of Verona, Strada le Grazie 15, 37134 Verona, Italy.
Immacolata TufanoCenter for Advanced Biomaterials for Healthcare@CRIB, Istituto Italiano di Tecnologia (IIT), Largo Barsanti e Matteucci 53, 80125 Naples, Italy.
Emiliano BediniDepartment of Chemical Sciences, University Federico II, Complesso Universitario Monte S.Angelo, via Cintia 4, 80126 Napoli, Italy.
Marco GerosaDepartment of Computer Science Research Area in Experimental and Applied Physics, University of Verona, Strada le Grazie 15, 37134 Verona, Italy.
Andrea SbarbatiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy.
Federico BoschiDepartment of Computer Science Research Area in Experimental and Applied Physics, University of Verona, Strada le Grazie 15, 37134 Verona, Italy.
Pasquina MarzolaDepartment of Computer Science Research Area in Experimental and Applied Physics, University of Verona, Strada le Grazie 15, 37134 Verona, Italy.
Nicola MaureaDivision of Cardiology, Istituto Nazionale Tumori- IRCCS- Fondazione G. Pascale, Via Mariano Semmola 53, 80131 Naples, Italy.
Paolo A NettiCenter for Advanced Biomaterials for Healthcare@CRIB, Istituto Italiano di Tecnologia (IIT), Largo Barsanti e Matteucci 53, 80125 Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In cancer therapy, stimulus-responsive drug delivery systems are of particular interest for reducing side effects in healthy tissues and improving drug selectivity in the tumoral ones. Here, a strategy for the preparation of a photo-responsive cross-linked trilayer deposited onto an oil-in-water nanoemulsion via a layer-by-layer technique is reported. The system is made of completely biocompatible materials such as soybean oil, egg lecithin and glycol chitosan, with heparin as the polymeric shell. The oil core is pre-loaded with curcumin as a model lipophilic active molecule with anti-tumoral properties. The trilayer cross-linkage is performed via a photoinitiator-free thiol-ene 'click' reaction. In particular, the system is implemented with an

Indexed as

CurcuminNanocapsulesNeoplasmsAnimalsBiocompatible MaterialsHumansMicePolymersBiocompatible MaterialsCurcuminNanocapsulesPolymersbiodegradable polymersdrug deliverynanoemulsionsphoto-responsive nanocapsules

Identifiers

PMID35193388
PMCPMC8867280

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.