Evidence map›Paper›PMID 35193331›Full record

ArticlePediatric endocrinology, diabetes, and metabolism2022

Adrenocortical adenoma manifesting as Cushing's syndrome and pseudo-precocious puberty in a toddler.

Hiya Boro, Suraj Kubihal, Rimlee Dutta, Vijay Kubihal, Sarah Alam, Nikhil Tandon

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PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric endocrinology, diabetes, and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hiya BoroDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Suraj KubihalDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Rimlee DuttaDepartment of Pathology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Vijay KubihalDepartment of Radiodiagnosis, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Sarah AlamDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Nikhil TandonDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
All India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cushing's syndrome is a rare disease in the paediatric age group. Adrenocortical carcinomas (ACC) constitute the most common cause of Cushing's syndrome between 1 and 5 years of age. Often, adrenocortical carcinomas co-secrete other hormones such as androgens (testosterone), deoxy-corticosterone (DOCA), or 17-hydroxy-progesterone [17(OH)P] in addition to cortisol. This may manifest with symptoms and signs of precocious puberty along with Cushing's syndrome. It is rare for a benign adrenocortical adenoma to co-secrete androgens and other hormones in addition to cortisol. Differentiation between adenoma and carcinoma is difficult in all aspects: clinical, radiological, and histopathological. Here, we describe the case of a 2.5-year-old male child who presented with Cushing's syndrome and virilization. Although we suspected ACC clinically, the radiological and histopathological findings were suggestive of benign adrenocortical adenoma. Our case represents the diagnostic challenge that exists in paediatric adrenocortical tumours.

Indexed as

AdenomaAdrenal Cortex NeoplasmsAdrenocortical AdenomaCushing SyndromePuberty, PrecociousChildChild, PreschoolHumansMaleadrenocortical adenomaCushing's syndromeprecocious pubertyWieneke criteria

Identifiers

PMID35193331
PMCPMC10226367
OpenAlexW4213427869

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.