ArticleCerebral cortex (New York, N.Y. : 1991)2022
Whole-brain connectivity during encoding: age-related differences and associations with cognitive and brain structural decline.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Cognitive and immunological effects of yoga compared to memory training in older women at risk for alzheimer's disease.Translational psychiatry · 2024Trial
- Contributions of Gray Matter Microstructure to Differences in Fluid Cognition and Episodic Memory Across the Healthy Adult Lifespan.Human brain mapping · 2026Article
- The Collapse of Brain Clearance: Glymphatic-Venous Failure, Aquaporin-4 Breakdown, and AI-Empowered Precision Neurotherapeutics in Intracranial Hypertension.International journal of molecular sciences · 2025Review
- Cognitive reserve in subjective cognitive decline with worry: DMN-VN connectivity supports episodic memory under structural vulnerability.BMC geriatrics · 2025Article
- High-resolution structural connectivity mediates age-related differences in functional connectivity and fluid cognition.Brain communications · 2025Article
- What does preferential viewing tell us about the neurobiology of recognition memory?Trends in neurosciences · 2024Article
- High-resolution multi-shot diffusion imaging of structural networks in healthy neurocognitive aging.NeuroImage · 2023Article
- Memory-related default-executive coupling across the lifespan and associations with changes in cognitive control.Imaging neuroscience (Cambridge, Mass.)Article
- Higher spatial resolution diffusion-weighted imaging improves characterization of white matter disconnection in Alzheimer's disease.Imaging neuroscience (Cambridge, Mass.)Article
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8 authors.
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Abstract
There is a limited understanding of age differences in functional connectivity during memory encoding. In the present study, a sample of cognitively healthy adult participants (n = 488, 18-81 years), a subsample of whom had longitudinal cognitive and brain structural data spanning on average 8 years back, underwent functional magnetic resonance imaging while performing an associative memory encoding task. We investigated (1) age-related differences in whole-brain connectivity during memory encoding; (2) whether encoding connectivity patterns overlapped with the activity signatures of specific cognitive processes, and (3) whether connectivity associated with memory encoding related to longitudinal brain structural and cognitive changes. Age was associated with lower intranetwork connectivity among cortical networks and higher internetwork connectivity between networks supporting higher level cognitive functions and unimodal and attentional areas during encoding. Task-connectivity between mediotemporal and posterior parietal regions-which overlapped with areas involved in mental imagery-was related to better memory performance only in older age. The connectivity patterns supporting memory performance in older age reflected preservation of thickness of the medial temporal cortex. The results are more in accordance with a maintenance rather than a compensation account.
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