ArticleDiabetes research and clinical practice2022
Associations of glycemia and lipid levels in pregnancy with dyslipidemia 10-14 years later: The HAPO follow-up study.
Article in Diabetes research and clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 17 citations in OpenAlex.
- Gestational Diabetes Mellitus Subtypes and Maternal Cardiometabolic Outcomes 10-14 Years After Delivery.Diabetes care · 2026Article
- Single-cell and proteomic profiling unveil aberrant immune phenotypes in gestational diabetes following assisted reproductive technology.Communications biology · 2026Article
- Evaluating Serum Endosialin (CD248) Levels as a Diagnostic Marker in Gestational Diabetes: A Case-Control Study.Journal of the ASEAN Federation of Endocrine Societies · 2025Article
- Output of significant others in the promotion and sustainability of exclusive breastfeeding among nursing mothers in Ikeduru LGA, Imo state nigeria: a quasi-experimental study.BMC public health · 2025Article
- Association between oxidative balance score and gestational diabetes mellitus risk: a case-control study.BMC endocrine disorders · 2025Article
- Diabetes and women's health.Journal of diabetes investigation · 2025Review
- Clinical and Behavioural Heterogeneity Among Women at Increased Risk for Gestational Diabetes: A Four-Country Analysis.International journal of environmental research and public health · 2025Article
- PREGNANCY DISORDERS AND MATERNAL CONSEQUENCES: Maternal pre-pregnancy risks and postpartum consequences of gestational diabetes.Reproduction (Cambridge, England) · 2025Review
- Early prediction of postpartum dyslipidemia in gestational diabetes using machine learning models.Scientific reports · 2025Article
- Maternal Lipids in Pregnancy and Later Life Dyslipidemia: The POUCHmoms Longitudinal Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Reproductive risk factors across the female lifecourse and later metabolic health.Cell metabolism · 2024Review
- Implementing care for women with gestational diabetes after delivery-the challenges ahead.Frontiers in global women's health · 2024Review
- Racial and ethnic differences in the association between pregnancy dysglycemia and cardiometabolic risk factors 10-14 years' postpartum in the HAPO follow-up study.Primary care diabetes · 2023Article
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
aimsTo examine associations of pregnancy glycemia with future dyslipidemia.
methodsWe analyzed data from Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study participants. We examined associations of gestational diabetes (GDM), sum of fasting, 1-hour, and 2-hour glucose z-scores after 75-g load, insulin sensitivity, and lipid levels at 24-32 weeks' gestation with dyslipidemia 10-14 years postpartum.
resultsAmong 4,693 women, 14.3% had GDM. At follow-up, mean (SD) age was 41.7 (5.7) years, 32.3% had total cholesterol (TC) ≥ 5.17, 27.2% had HDL cholesterol < 1.29, 22.4% had LDL cholesterol (LDL-C) ≥ 3.36, 10.9% had triglycerides ≥ 1.69 mmol/L, and 2.9% had type 2 diabetes. After covariate adjustment, pregnancy glycemic measures were associated with all follow-up dyslipidemias. After additional adjustment for pregnancy lipids, GDM remained associated with TC ≥ 5.17 mmol/L (odds ratio [95% CI], 1.63 [1.22-2.18]) and LDL-C ≥ 3.36 mmol/L (1.63 [1.20-2.22]), even in the absence of type 2 diabetes development (1.55 [1.15-2.10] and 1.56 [1.13-2.16], respectively). Continuous glycemic measures in pregnancy were significantly associated with all follow-up dyslipidemias, independent of pregnancy lipids and type 2 diabetes.
conclusionsPregnancy glycemia was associated with dyslipidemia 10-14 years later, independent of pregnancy lipid levels and in the absence of type 2 diabetes development. Lipid screening after GDM deserves special consideration.
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