Evidence map›Paper›PMID 35192454›Full record

ArticleeLife2022

Frequency- and spike-timing-dependent mitochondrial Ca

Ohad Stoler, Alexandra Stavsky, Yana Khrapunsky, Israel Melamed, Grace Stutzmann, Daniel Gitler, Israel Sekler, Ilya Fleidervish

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Mitochondrial CaNature metabolism · 2026
    Article
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  7. Article
  8. Article
  9. Microglia-to-neuron signaling linksProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Mitochondrial CaCommunications biology · 2022
    Article
  20. IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ohad Stoler *Department of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.ORCID 0000-0002-3420-8382
Alexandra Stavsky *Department of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.ORCID 0000-0002-8209-3524
Yana KhrapunskyDepartment of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Israel MelamedDepartment of Neurosurgery, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Grace StutzmannRosalind Franklin University of Medicine and Science, Chicago Medical School, Center for Neurodegenerative Disease and Therapeutics, North Chicago, United States.
Daniel GitlerDepartment of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.ORCID 0000-0001-9544-3610
Israel SeklerDepartment of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Ilya FleidervishDepartment of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.ORCID 0000-0002-5501-726X
Ben-Gurion University of the Negev · ILRosalind Franklin University of Medicine and Science · US

Funding

Intracellular organelle deficits driving Alzheimer's diseaseRF1AG065628 · NIA · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI SEKLER, ISRAEL, STUTZMANN, GRACE E. · 2020 to 2020
$1.7M
NIA NIH HHS RF1 AG065628
6 · The paper itself

Abstract

Mitochondrial activity is crucial for the plasticity of central synapses, but how the firing pattern of pre- and postsynaptic neurons affects the mitochondria remains elusive. We recorded changes in the fluorescence of cytosolic and mitochondrial Ca

Indexed as

DendritesPyramidal CellsAction PotentialsAnimalsMiceMitochondriaNeuronsSynapsesaxonCa2+ signalingcortical pyramidal neurondendritemitochondriamouseneurosciencespike-timing-dependent plasticity

Identifiers

PMID35192454
PMCPMC8906805
OpenAlexW4213045911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.