Evidence map›Paper›PMID 35192433›Full record

ArticleGut microbes

Flagellum and toxin phase variation impacts intestinal colonization and disease development in a mouse model of

Dominika Trzilova, Mercedes A H Warren, Nicole C Gadda, Caitlin L Williams, Rita Tamayo

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 20 citations in OpenAlex.

  1. A programmed reset mechanism primesScience advances · 2026
    Article
  2. Phase variable colony morphotypes ofInfection and immunity · 2026
    Article
  3. Clostridioides difficile pathogenesis and control.Nature reviews. Microbiology · 2026
    Review
  4. Journal of bacteriology · 2026
    Article
  5. Phase variable colony morphotypes ofbioRxiv : the preprint server for biology · 2026
    Article
  6. Visualizing C. difficile During Murine Infection.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  7. Frontiers in microbiology · 2026
    Article
  8. Dissecting the role of flagellar subunits inJournal of bacteriology · 2025
    Article
  9. Article
  10. bioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Article
  13. The state of play of rodent models for the study ofJournal of medical microbiology · 2024
    Review
  14. Protection againstbioRxiv : the preprint server for biology · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dominika TrzilovaDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Mercedes A H WarrenDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Nicole C GaddaDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Caitlin L WilliamsDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Rita TamayoDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · US

Funding

SEEDING POSTDOCTORAL INNOVATORS IN RESEARCH &EDUCATIONK12GM000678 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DONALD T LYSLE, Kathryn Joanna Reissner · 1999 to 2026
$30.9M
Regulation of Clostridium difficile Colonization FactorsR01AI107029 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TAMAYO, RITA · 2013 to 2022
$3.9M
Global regulation in Clostridium difficile via phase variation of cyclic diguanylate signalingR01AI143638 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TAMAYO, RITA · 2019 to 2023
$2.5M
Phase variation of virulence factors in Clostridioides difficileR37AI107029 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RITA TAMAYO · 2025 to 2026
$1.0M
NIAID NIH HHS R01 AI107029NIAID NIH HHS R01 AI143638NIAID NIH HHS R37 AI107029NIGMS NIH HHS K12 GM000678
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bacterial ToxinsClostridioides difficileClostridium InfectionsGastrointestinal MicrobiomeAnimalsBacterial ProteinsCricetinaeDisease Models, AnimalFlagellaGene Expression Regulation, BacterialMicePhase VariationBacterial ProteinsBacterial ToxinsflagellahamstermotilitymousePhenotypic heterogeneitytoxin

Identifiers

PMID35192433
PMCPMC8890394
OpenAlexW4220798569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.