Evidence map›Paper›PMID 35192415›Full record

ArticleScience signaling2022

Arenaviral infection causes bleeding in mice due to reduced serotonin release from platelets.

Roberto Aiolfi, Giovanni Sitia, Matteo Iannacone, Ivan Brunetta, Luca G Guidotti, Zaverio M Ruggeri

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Inflammatory platelet production stimulated by tyrosyl-tRNA synthetase mimicking viral infection.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Roberto AiolfiDepartment of Molecular Medicine, MERU-Roon Research Center for Vascular Biology, Scripps Research, La Jolla, CA 92037, USA.ORCID 0000-0003-2066-4536
Giovanni SitiaDivision of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.ORCID 0000-0002-4262-0406
Matteo IannaconeDivision of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.ORCID 0000-0002-9370-2671
Ivan BrunettaDepartment of Molecular Medicine, MERU-Roon Research Center for Vascular Biology, Scripps Research, La Jolla, CA 92037, USA.
Luca G GuidottiDivision of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.ORCID 0000-0002-0205-2678
Zaverio M RuggeriDepartment of Molecular Medicine, MERU-Roon Research Center for Vascular Biology, Scripps Research, La Jolla, CA 92037, USA.ORCID 0000-0003-0807-1295
Scripps Research Institute · USVita-Salute San Raffaele University · IT

Funding

Regulation of HBV Replication by the Immune SystemR01AI040696 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI GUIDOTTI, LUCA G. · 1997 to 2012
$5.2M
STRUCTURE/FUNCTION OF PLATELET MEMBRANE GLYCOPROTEINSR37HL042846 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI RUGGERI, ZAVERIO M · 1999 to 2008
$4.1M
STRUCTURE &FUNCTION OF PLATELET MEMBRANE GLYCOPROTEINSR01HL042846 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI RUGGERI, ZAVERIO M · 1989 to 2014
$2.4M
Platelet and coagulation activation in response to vascular injuryR01HL117722 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI RUGGERI, ZAVERIO M · 2015 to 2018
$2.3M
Glycoprotein Ib in vascular biology and host defenseR01HL135294 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI RUGGERI, ZAVERIO M · 2017 to 2020
$2.3M
NHLBI NIH HHS R01 HL042846NHLBI NIH HHS R01 HL117722NHLBI NIH HHS R01 HL135294NHLBI NIH HHS R37 HL042846NIAID NIH HHS R01 AI040696
6 · The paper itself

Abstract

Bleeding correlates with disease severity in viral hemorrhagic fevers. We found that the increase in type I interferon (IFN-I) in mice caused by infection with the Armstrong strain of lymphocytic choriomeningitis virus (LCMV; an arenavirus) reduced the megakaryocytic expression of genes encoding enzymes involved in lipid biosynthesis (

Indexed as

Lymphocytic ChoriomeningitisAnimalsBlood PlateletsHemorrhageLymphocytic choriomeningitis virusMiceSerotoninSerotonin

Identifiers

PMID35192415
PMCPMC11583808
OpenAlexW4213444530

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.