Evidence map›Paper›PMID 35192118›Full record

ReviewCurrent oncology reports2022

Radiation-Induced Cardiovascular Disease: Mechanisms, Prevention, and Treatment.

Efstratios Koutroumpakis, Anita Deswal, Syed Wamique Yusuf, Jun-Ichi Abe, Kevin T Nead, Adam S Potter, Zhongxing Liao, Steven H Lin, Nicolas L Palaskas

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current oncology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Radiation Treatment Mechanisms of Cardiotoxicity: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  2. Article
  3. Thbs1Journal of advanced research · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Targeting Lysosomes for Enhanced Anti-Cancer Therapeutics and Immune Response.International journal of biological sciences · 2026
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Single-Cell RNA Sequencing Reveals Granzyme KJournal of the American Heart Association · 2025
    Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Efstratios KoutroumpakisDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. EKoutroumpakis@mdanderson.org.ORCID 0000-0002-6757-6480
Anita DeswalDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Syed Wamique YusufDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Jun-Ichi AbeDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Kevin T NeadDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Adam S PotterDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Zhongxing LiaoDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Steven H LinDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nicolas L PalaskasDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
The University of Texas MD Anderson Cancer Center · US

Funding

Project 3: Enhanced Sensitivity of Tumors to Proton Beam Therapy: Mechanisms and Biomarkers.P01CA261669 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI TITT, UWE · 2021 to 2025
$14.0M
Impact of clonal hematopoiesis mutations on toxicity and outcomes following oncologic therapyK08CA263313 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NEAD, KEVIN THOMAS · 2021 to 2025
$1.2M
NCI NIH HHS K08 CA263313NCI NIH HHS L30 CA253796NCI NIH HHS P01 CA261669
6 · The paper itself

Abstract

purpose of reviewDespite the advancements of modern radiotherapy, radiation-induced cardiovascular disease (RICVD) remains a common cause of morbidity and mortality among cancer survivors. RECENT

findingsProposed pathogenetic mechanisms of RICVD include endothelial cell damage with accelerated atherosclerosis, pro-thrombotic alterations in the coagulation pathway as well as inflammation and fibrosis of the myocardial, pericardial, valvular, and conduction tissues. Prevention of RICVD can be achieved by minimizing the exposure of the cardiovascular system to radiation, by treatment of underlying cardiovascular risk factors and cardiovascular disease, and possibly by prophylactic pharmacotherapy post exposure. Herein we summarize current knowledge on the mechanisms underlying the pathogenesis of RICVD and propose prevention and treatment strategies.

Indexed as

Cardiovascular DiseasesNeoplasmsRadiation InjuriesCardiotoxicityHeartHumansCardiotoxicityMechanismsPreventionRadiation-induced cardiovascular diseaseRadiation therapyRadiotherapyTreatment

Identifiers

PMID35192118
OpenAlexW4213184169

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.