Evidence map›Paper›PMID 35192042›Full record

ArticleExperimental brain research2022

Short latency afferent inhibition: comparison between threshold-tracking and conventional amplitude recording methods.

Bülent Cengiz, H Evren Boran, Halil Can Alaydın, Hatice Tankisi, Gintaute Samusyte, James Howells, Martin Koltzenburg, Hugh Bostock

Abstract read
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In one paragraph

Article in Experimental brain research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bülent CengizDepartment of Neurology, Gazi University Faculty of Medicine, Beşevler, 06500, Ankara, Turkey. bcengiz@gazi.edu.tr.ORCID http://orcid.org/0000-0002-1688-9516
H Evren BoranDepartment of Neurology, Gazi University Faculty of Medicine, Beşevler, 06500, Ankara, Turkey.
Halil Can AlaydınDepartment of Neurology, Gazi University Faculty of Medicine, Beşevler, 06500, Ankara, Turkey.
Hatice TankisiDepartment of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
Gintaute SamusyteDepartment of Neurology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
James HowellsCentral Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Martin KoltzenburgDepartment of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Hugh BostockDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

Funding

Lundbeckfonden R290-2018-751Lundbeckfonden R346-2020-1946Medical Research Council MR/K015222/1
6 · The paper itself

Abstract

Short-latency afferent inhibition (SAI), which is conventionally measured as a reduction in motor evoked potential amplitude (A-SAI), is of clinical interest as a potential biomarker for cognitive impairment. Since threshold-tracking has some advantages for clinical studies of short-interval cortical inhibition, we have compared A-SAI with a threshold-tracking alternative method (T-SAI). In the T-SAI method, inhibition was calculated by tracking the required TMS intensity for the targeted MEP amplitude (200 uV) both for the test (TMS only) and paired (TMS and peripheral stimulation) stimuli. A-SAI and T-SAI were recorded from 31 healthy subjects using ten stimuli at each of 12 inter-stimulus intervals, once in the morning and again in the afternoon. There were no differences between morning and afternoon recordings. When A-SAI was normalized by log conversion it was closely related to T-SAI. Between subjects, variability was similar for the two techniques, but within-subject variability was significantly smaller for normalized A-SAI. Conventional amplitude measurements appear more sensitive for detecting changes within-subjects, such as in interventional studies, but threshold-tracking may be as sensitive as detecting abnormal SAI in a patient.

Indexed as

Motor CortexTranscranial Magnetic StimulationAfferent PathwaysElectromyographyEvoked Potentials, MotorHumansNeural InhibitionReaction TimeAmplitude measurementShort latency afferent inhibitionThreshold-trackingVariability

Identifiers

PMID35192042

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.