ArticleeLife2022
TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia.
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Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
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Who cites it
44 citing papers in PubMed, 61 citations in OpenAlex.
- Calcium signaling in microglial immune functions: current understanding and implications for disease.Current opinion in immunology · 2026Review
- Lipid-driven membrane remodeling engages a lysosome-dependent adaptive repair program during retinal aging.Molecular neurodegeneration · 2026Article
- Article
- Calcium signaling in human and mouse microglia exhibit differential susceptibility to phytocannabinoids.Cell communication and signaling : CCS · 2026Article
- Dissecting microglial contributions to neurodegenerative disease pathophysiology using human pluripotent stem cells.Stem cell reports · 2026Review
- Dual Role of Microglial TREM2 in Neuronal Degeneration and Regeneration After Axotomy.bioRxiv : the preprint server for biology · 2026Article
- TSC-associated microglial hyperactivity: enhanced calcium signaling, metabolism, and phagocytosis.Acta neuropathologica · 2026Article
- Interplay between CD33 and TREM2 in Alzheimer's Disease: Potential Mechanistic Insights into Microglial Function in Amyloid Pathology.ACS chemical neuroscience · 2026Review
- TREM2 as a central hub of neuroimmune-metabolic crosstalk in central nervous system disorders: from microglial biology to therapeutic targeting.Frontiers in immunology · 2026Review
- Role of Mitochondrial Calcium Dysregulation in Alzheimer's Disease Pathogenesis.Molecular neurobiology · 2025Review
- Roles of TREM2 in Alzheimer's disease.Translational neurodegeneration · 2025Review
- Amyloid precursor protein and C99 are subunits in human microglial Hv1 channels that enhance current and inflammatory mediator release.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transcriptional regulation of disease-relevant microglial activation programs.bioRxiv : the preprint server for biology · 2025Article
- Review
- Design, Synthesis and Preclinical Evaluation of a Brain-Permeable PET Tracer for P2Y12 Receptor Imaging in the Brain.Journal of medicinal chemistry · 2025Article
- An integrated view of the relationships between amyloid, tau, and inflammatory pathophysiology in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Induced Microglial-like Cells Derived from Familial and Sporadic Alzheimer's Disease Peripheral Blood Monocytes Show Abnormal Phagocytosis and Inflammatory Response to PSEN1 E280A Cholinergic-like Neurons.International journal of molecular sciences · 2025Article
- Microglia, Trem2, and Neurodegeneration.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- Induced pluripotent stem cell-derived macrophages as a platform for modelling human disease.Nature reviews. Immunology · 2025Review
- Traditional Chinese medicine's holistic approach: regulating microglia-driven neuroinflammation for the resolution of Alzheimer's disease.Frontiers in cellular neuroscience · 2025Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Amit Jairaman *Department of Physiology and Biophysics, University of California, Irvine, Irvine, United States.ORCID 0000-0002-5206-700X
Amanda McQuade *Department of Neurobiology and Behavior, University of California, Irvine, Irvine, United States.ORCID 0000-0001-5368-6788
Alberto GranzottoDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, United States.
You Jung KangDepartment of Mechanical Engineering and Engineering Science, University of North Carolina, Charlotte, United States.
Jean Paul ChadarevianDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, United States.
Sunil GandhiDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, United States.
Ian ParkerDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.
Ian SmithDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, United States.ORCID 0000-0001-9910-195X
Hansang ChoInstitute of Quantum Biophysics, Department of Biophysics, Dept of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Gyeonggi-do, Republic of Korea.
Stefano L SensiCenter for Advanced Sciences and Technology (CAST), University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.
Shivashankar OthyDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.ORCID 0000-0001-6832-5547
Mathew Blurton-JonesDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, United States.ORCID 0000-0002-7770-7157
Michael D CahalanDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.ORCID 0000-0002-4987-2526
University of California, Irvine · USSungkyunkwan University · KRUniversity of California, San Francisco · USUniversity of Chieti-Pescara · IT
Funding
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Elizabeth Head · 2020 to 2026
$27.9MMolecular Mechanisms of lon Channels in T LymphocytesR01NS014609 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 1985 to 2022
$7.0MTraining Program in Stem Cell Translational Medicine for Neurological DisordersT32NS082174 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PETER John DONOVAN, Leslie Michels Thompson · 2013 to 2026
$3.3MExamining the role of adaptive immunity in Alzheimer's Disease pathogenesisRF1AG055524 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BLURTON-JONES, MATHEW MARK · 2017 to 2017
$2.7MCellular and Molecular Mechanisms of Regulatory T Cells in EAER01AI121945 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2016 to 2020
$2.5MDefining molecular mechanisms of combination adjuvants: a systems immunology, transcriptomics and imaging approachU01AI160397 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAVIES, DAVID HUW · 2021 to 2024
$2.4MA novel platform for the investigation of human microgliaRF1DA048813 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BLURTON-JONES, MATHEW MARK, GANDHI, SUNIL · 2019 to 2021
$2.1MManipulating DNA repair enzymes to examine the interactions between aging and Alzheimers disease with iPSC-derived microgliaR01AG056303 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BLURTON-JONES, MATHEW MARK · 2017 to 2021
$1.9MThe role of TREM2 in human microglial function and Alzheimer disease pathogenesisRF1AG048099 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BLURTON-JONES, MATHEW MARK · 2014 to 2014
$1.9MTo prove the interplaying roles of central and peripheral immunity in Alzheimer's diseaseR15AG059236 · NIA · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI LEE, CHARLES · 2019 to 2019
$426kCellular and Molecular Mechanisms of Regulatory T Cells in EAER56AI121945 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2016 to 2016
$103kNIAID NIH HHS R01 AI121945NIAID NIH HHS R56 AI121945NIAID NIH HHS U01 AI160397NIA NIH HHS P30 AG066519NIA NIH HHS R01 AG056303NIA NIH HHS R15 AG059236NIA NIH HHS RF1 AG048099NIA NIH HHS RF1 AG055524NIDA NIH HHS RF1 DA048813NINDS NIH HHS R01 NS014609NINDS NIH HHS T32 NS082174
Abstract
The membrane protein TREM2 (Triggering Receptor Expressed on Myeloid cells 2) regulates key microglial functions including phagocytosis and chemotaxis. Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer's disease (AD). Because abnormalities in Ca
Indexed as
Alzheimer DiseaseInduced Pluripotent Stem CellsAdenosine DiphosphateCalciumCalcium SignalingHumansMembrane GlycoproteinsMicrogliaReceptors, ImmunologicReceptors, PurinergicAdenosine DiphosphateCalciumMembrane GlycoproteinsReceptors, ImmunologicReceptors, PurinergicTREM2 protein, humanAlzheimer's diseaseCa2+ signalinghumanimmunologyinflammationiPSC-derived microglianeuroscienceP2Y receptorstore-operated Ca2+ entryTREM2
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