Evidence map›Paper›PMID 35191762›Full record

ArticleJournal of bacteriology2022

The Small DdrR Protein Directly Interacts with the UmuDAb Regulator of the Mutagenic DNA Damage Response in Acinetobacter baumannii.

Anja Pavlin, Gregor Bajc, Nadine Fornelos, Douglas F Browning, Matej Butala

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Repression ofJournal of bacteriology · 2024
    Article
  7. DNA damage response coregulatorFrontiers in cellular and infection microbiology · 2023
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Anja PavlinDepartment of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Gregor BajcDepartment of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Nadine FornelosBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Douglas F BrowningCollege of Health and Life Sciences, Aston Universitygrid.7273.1, Birmingham, UK.ORCID 0000-0003-4672-3514
Matej ButalaDepartment of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
University of Ljubljana · SIAston University · GBBroad Institute · US

Funding

Biotechnology and Biological Sciences Research Council BB/R017689/1
6 · The paper itself

Abstract

Acinetobacter baumannii poses a great threat in health care settings worldwide, with clinical isolates displaying an ever-evolving multidrug resistance. In strains of A. baumannii, expression of multiple error-prone polymerase genes are corepressed by UmuDAb, a member of the LexA superfamily, and a small protein, DdrR. It is currently unknown how DdrR establishes this repression. Here, we used surface plasmon resonance spectrometry to show that DdrR formed a stable complex with the UmuDAb regulator. Our results indicated that the carboxy-terminal dimerization domain of UmuDAb formed the interaction interface with DdrR. Our

Indexed as

Acinetobacter baumanniiBacterial ProteinsDNA DamageGene Expression Regulation, BacterialMutagensTranscription FactorsBacterial ProteinsMutagensTranscription FactorsAcinetobacter baumanniiantibiotic resistancebacteriophage inductionDNA damageDNA repairInduction of gene expressionLexA UmuDAbSOS response

Identifiers

PMID35191762
PMCPMC8923225
OpenAlexW4213365554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.