ArticleMolecular and cellular biology2022
circ_0001821 Contributes to the Development of Cutaneous Squamous Cell Carcinoma by Regulating MicroRNA-148a-3p/EGFR Axis and Activating Phosphatidylinositol 3-Kinase/Akt Pathway.
Article in Molecular and cellular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Exploring Potential Biomarkers and Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma Based on Bioinformatics.OncoTargets and therapy · 2024Article
- Circ_0001821 Potentiates Cell Growth, Metastasis, and Stemness in Colorectal Cancer by Regulating miR-339-3p/CST1.Biochemical genetics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular RNAs (circRNAs) are implicated in diverse human cancers. However, the effects of circRNAs on cutaneous squamous cell carcinoma (CSCC) are barely known. We focused on the function of circ_0001821 in CSCC. Quantitative reverse transcription PCR was performed for the expression of circ_0001821, miR-148a-3p, and epidermal growth factor receptor (EGFR). Cell counting kit-8 assay and colony formation assay were conducted to evaluate cell viability and colony formation ability. Flow cytometry analysis was adopted to analyze cell cycle and apoptosis. A transwell assay was employed to detect cell motility. Dual-luciferase reporter assay, RNA immunoprecipitation assay, and RNA pulldown assay were utilized to verify the interaction between miR-148a-3p and circ_0001821 or EGFR. A Western blot assay was conducted for protein levels. Murine xenograft model assay was used to explore the function of circ_0001821
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.