Evidence map›Paper›PMID 35191598›Full record

ArticleChemMedChem2022

Expanding the Repertoire of Low-Molecular-Weight Pentafluorosulfanyl-Substituted Scaffolds.

Arathy Jose, Daniel Guest, Remi LeGay, Graham J Tizzard, Simon J Coles, Mariliza Derveni, Edward Wright, Lester Marrison, Alpha A Lee, Aaron Morris and 13 more

Open access · hybridAbstract read
In one paragraph

Article in ChemMedChem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 11 institutions in 6 countries.

Arathy JoseChemistry Department, School of Life Sciences, Falmer, Brighton, BN1 9QJ, UK.
Daniel GuestChemistry Department, School of Life Sciences, Falmer, Brighton, BN1 9QJ, UK.
Remi LeGayNormandie Université, Laboratoire de Chimie Moléculaire et Thioorganique, LCMT UMR 6507 ENSICAEN, UNICAEN, CNRS, 6 Bd. Du Marechal Juin, 14050, Caen, France.
Graham J TizzardNational Crystallography Service, School of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK.
Simon J ColesNational Crystallography Service, School of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK.ORCID 0000-0001-8414-9272
Mariliza DerveniBiochemistry, School of Life Sciences, Falmer, Brighton, BN1 9QG, UK.
Edward WrightBiochemistry, School of Life Sciences, Falmer, Brighton, BN1 9QG, UK.
Lester MarrisoneMolecules, 3430, Carmel Mountain Road, Suite 250, San Diego, CA 92121, USA.
Alpha A LeePostEra Inc., 2 Embarcadero Centre, San Franciso, CA 94111, USA.ORCID 0000-0002-9616-3108
Aaron MorrisPostEra Inc., 2 Embarcadero Centre, San Franciso, CA 94111, USA.
Matt RobinsonPostEra Inc., 2 Embarcadero Centre, San Franciso, CA 94111, USA.
Frank von DelftDiamond Light Source (DLS), Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.
Daren FearonDiamond Light Source (DLS), Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.ORCID 0000-0003-3529-7863
Lizbé KoekemoerCentre of Medicines Discovery (CMD), University of Oxford, Department of Biochemistry, Oxford, OX1 3QU, UK.ORCID 0000-0001-9226-9127
Tetiana MatviukEnamine, Chervonotkatska St, 67, Kyiv, 02094, Ukraine.
Anthony AimonDiamond Light Source (DLS), Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.
Christopher J SchofieldChemistry Research Laboratory, The Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, 12 Mansfield Road, OX1 3TA, Oxford, UK.ORCID 0000-0002-0290-6565
Tika R MallaChemistry Research Laboratory, The Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, 12 Mansfield Road, OX1 3TA, Oxford, UK.
Nir LondonDepartment of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, 76100, Israel.ORCID 0000-0003-2687-0699
Barnaby W GreenlandChemistry Department, School of Life Sciences, Falmer, Brighton, BN1 9QJ, UK.ORCID 0000-0002-8416-4955
Mark C BagleyChemistry Department, School of Life Sciences, Falmer, Brighton, BN1 9QJ, UK.ORCID 0000-0003-1263-138X
John SpencerChemistry Department, School of Life Sciences, Falmer, Brighton, BN1 9QJ, UK.ORCID 0000-0001-5231-8836
The Covid Moonshot ConsortiumMembers list: https://tinyurl.com/y3r7redd.
University of Sussex · GBSt. Francis Medical Center · USDiamond Light Source · GBMansfield University · USUniversity of Southampton · GBCarmel Mountain Vision Care · USCentre National de la Recherche Scientifique · FREnamine (Ukraine) · UAUniversity of Johannesburg · ZAUniversity of Oxford · GBWeizmann Institute of Science · IL

Funding

Biotechnology and Biological Sciences Research Council BB/M011224/1Cancer Research UKWellcome TrustWellcome Trust 106244/Z/14/Z
6 · The paper itself

Abstract

The pentafluorosulfanyl (-SF

Indexed as

Chemistry, PharmaceuticalDihydroorotate DehydrogenaseAmidesHumansAmidesDihydroorotate DehydrogenaseCOVID-19, SARS-COV-2 main protease (Mpro)DMARDsSF5 group

Identifiers

PMID35191598
PMCPMC9305131
OpenAlexW4213215459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.