Evidence map›Paper›PMID 35191486›Full record

ArticleBiology of reproduction2022

Effects of exogenous progesterone on the expression of mineral regulatory molecules by ovine endometrium and placentomes†.

Claire Stenhouse, Katherine M Halloran, Emily C Hoskins, Makenzie G Newton, Robyn M Moses, Heewon Seo, Kathrin A Dunlap, Michael C Satterfield, Dana Gaddy, Gregory A Johnson and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of reproduction, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Claire StenhouseDepartment of Animal Science, Texas A&M University, College Station, Texas, USA.
Katherine M HalloranDepartment of Animal Science, Texas A&M University, College Station, Texas, USA.
Emily C HoskinsDepartment of Animal Science, Texas A&M University, College Station, Texas, USA.
Makenzie G NewtonDepartment of Animal Science, Texas A&M University, College Station, Texas, USA.
Robyn M MosesDepartment of Animal Science, Texas A&M University, College Station, Texas, USA.
Heewon SeoVeterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA.
Kathrin A DunlapDepartment of Animal Science, Texas A&M University, College Station, Texas, USA.
Michael C SatterfieldDepartment of Animal Science, Texas A&M University, College Station, Texas, USA.
Dana GaddyVeterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA.
Gregory A JohnsonVeterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA.
Guoyao WuDepartment of Animal Science, Texas A&M University, College Station, Texas, USA.
Larry J SuvaVeterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas USA.
Fuller W BazerDepartment of Animal Science, Texas A&M University, College Station, Texas, USA.
Texas A&M University · USTexas College · USAI Biosciences (United States) · US

Funding

Modeling Odontohypophosphatasia in the SheepR21DE028076 · NIDCR · TEXAS A&M AGRILIFE RESEARCH · PI GADDY, DANA · 2018 to 2019
$422k
NIDCR NIH HHS R21 DE028076
6 · The paper itself

Abstract

This study aimed to determine whether the acceleration of conceptus development induced by the administration of exogenous progesterone (P4) during the preimplantation period of pregnancy alters calcium, phosphate, and vitamin D signaling at the maternal-conceptus interface. Suffolk ewes (n = 48) were mated to fertile rams and received daily intramuscular injections of either corn oil (CO) vehicle or 25 mg of progesterone in CO (P4) for the first 8 days of pregnancy and hysterectomized on either Day 9 (CO, n = 5; P4, n = 6), 12 (CO, n = 9; P4, n = 4) or 125 (CO, n = 14; P4, n = 10) of gestation. The expression of S100A12 (P < 0.05) and fibroblast growth factor receptor (FGFR2) (P < 0.01) messenger RNAs (mRNAs) was lower in endometria from P4-treated ewes on Day 12. The expression of ADAM10 (P < 0.05) mRNA was greater in endometria from P4-treated ewes on Day 125. The expression of ADAM10 (P < 0.01), FGFR2 (P < 0.05), solute carrier (SLC)20A1 (P < 0.05), TRPV5 (P < 0.05), and TRPV6 (P < 0.01) mRNAs was greater, but KL mRNA expression was lower (P < 0.05) in placentomes from P4-treated ewes at Day 125. There was lower endometrial and greater placentomal expression of mRNAs involved in mineral metabolism and transport in twin compared to singleton pregnancies. Further, the expression of mRNAs involved in mineral metabolism and transport was greater in P4-treated twin placentomes. KL, FGF23, vitamin D receptor (VDR), S100A9, S100A12, S100G, and CYP27B1 proteins were immunolocalized in endometria and placentomes. Exogenous P4 in early pregnancy altered the expression of regulators of calcium, phosphate, and vitamin D on Day 125 of pregnancy indicating a novel effect of P4 on mineral transport at the maternal-conceptus interface.

Indexed as

CalciumProgesteroneAnimalsEndometriumFemaleMineralsPhosphatesPlacentaPregnancyRNA, MessengerS100A12 ProteinSheepSheep, DomesticVitamin DCalciumMineralsPhosphatesProgesteroneRNA, MessengerS100A12 ProteinVitamin Dcalciumendometriumovinephosphateplacentavitamin D

Identifiers

PMID35191486
PMCPMC12097898
OpenAlexW4212826615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.