Evidence map›Paper›PMID 35191317›Full record

ArticleJournal of the American Heart Association2022

S-Nitrosoglutathione Reductase Deficiency Causes Aberrant Placental S-Nitrosylation and Preeclampsia.

Shathiyah Kulandavelu, Raul A Dulce, Christopher I Murray, Michael A Bellio, Julia Fritsch, Rosemeire Kanashiro-Takeuchi, Himanshu Arora, Ellena Paulino, Daniel Soetkamp, Wayne Balkan and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Dysregulated ProteinCirculation research · 2025
    Article
  3. Trophoblast Fusion in Hypertensive Disorders of Pregnancy and Preeclampsia.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Dietary supplements and vascular function in hypertensive disorders of pregnancy.Pflugers Archiv : European journal of physiology · 2023
    Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Shathiyah KulandaveluInterdisciplinary Stem Cell InstituteUniversity of Miami Miller School of Medicine Miami FL.ORCID 0000-0003-0966-7613
Raul A DulceInterdisciplinary Stem Cell InstituteUniversity of Miami Miller School of Medicine Miami FL.ORCID 0000-0003-1354-0180
Christopher I MurrayMedicine and Heart InstituteCedars Sinai Medical Center Los Angeles CA.ORCID 0000-0002-5055-4875
Michael A BellioInterdisciplinary Stem Cell InstituteUniversity of Miami Miller School of Medicine Miami FL.
Julia FritschInterdisciplinary Stem Cell InstituteUniversity of Miami Miller School of Medicine Miami FL.ORCID 0000-0002-4594-9063
Rosemeire Kanashiro-TakeuchiInterdisciplinary Stem Cell InstituteUniversity of Miami Miller School of Medicine Miami FL.ORCID 0000-0002-7305-9172
Himanshu AroraInterdisciplinary Stem Cell InstituteUniversity of Miami Miller School of Medicine Miami FL.ORCID 0000-0003-3143-6387
Ellena PaulinoInterdisciplinary Stem Cell InstituteUniversity of Miami Miller School of Medicine Miami FL.
Daniel SoetkampMedicine and Heart InstituteCedars Sinai Medical Center Los Angeles CA.ORCID 0000-0001-8276-4175
Wayne BalkanInterdisciplinary Stem Cell InstituteUniversity of Miami Miller School of Medicine Miami FL.ORCID 0000-0003-0405-0489
Jenny E Van EykMedicine and Heart InstituteCedars Sinai Medical Center Los Angeles CA.ORCID 0000-0001-9050-148X
Joshua M HareInterdisciplinary Stem Cell InstituteUniversity of Miami Miller School of Medicine Miami FL.ORCID 0000-0002-7751-5032
University of Miami · USCedars-Sinai Smidt Heart Institute · US

Funding

Cell Based Therapy for Non-Ischemic Dilated CardiomyopathyUM1HL113460 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARE, JOSHUA M · 2012 to 2018
$4.3M
Mesenchymal stem cell therapy for endothelial dysfunction in diabetesR01HL134558 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARE, JOSHUA M · 2016 to 2020
$3.2M
Nitric Oxide and sex differences in cardiac repairR01HL137355 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARE, JOSHUA M · 2017 to 2020
$1.6M
EXTRACELLULAR SOD IN CARDIAC REPERFUSION INJURYF32HL009489 · NHLBI · DUKE UNIVERSITY · PI CHEN, EDWARD P · 1996 to 1997
–
CIHRNHLBI NIH HHS F32 HL009489NHLBI NIH HHS R01 HL134558NHLBI NIH HHS R01 HL137355NHLBI NIH HHS UM1 HL113460
6 · The paper itself

Abstract

Background Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is characterized by an increase in S-nitrosylated proteins and reactive oxygen species, suggesting a pathophysiologic role for dysregulation in nitrosylation and nitrosative stress. Methods and Results Here, we show that mice lacking S-nitrosoglutathione reductase (

Indexed as

Alcohol DehydrogenaseNitric OxidePlacentaPre-EclampsiaAldehyde OxidoreductasesAnimalsFemaleMicePregnancyReactive Oxygen SpeciesAdh5 protein, mouseAlcohol DehydrogenaseAldehyde Oxidoreductasesformaldehyde dehydrogenase, glutathione-independentNitric OxideReactive Oxygen Speciesmouse modelNOpreeclampsiapregnancyS‐nitrosylation

Identifiers

PMID35191317
PMCPMC9075059
OpenAlexW4212898582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.