Evidence map›Paper›PMID 35191211›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Engineering Robust Ag-Decorated Polydopamine Nano-Photothermal Platforms to Combat Bacterial Infection and Prompt Wound Healing.

Xiaoliang Qi, Yijing Huang, Shengye You, Yajing Xiang, Erya Cai, Ruiting Mao, Wenhao Pan, Xianqin Tong, Wei Dong, Fangfu Ye and 1 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
37.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 487 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xiaoliang QiState Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Yijing HuangSchool of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu, 210094, China.
Shengye YouSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Yajing XiangSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Erya CaiSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Ruiting MaoSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Wenhao PanSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Xianqin TongSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Wei DongSchool of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu, 210094, China.
Fangfu YeWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325000, China.
Jianliang ShenState Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.ORCID 0000-0003-4351-4872
Wenzhou Medical University · CNNanjing University of Science and Technology · CNUniversity of Chinese Academy of Sciences · CN

Funding

National Natural Science Foundation of China 21977081National Natural Science Foundation of China 31800833University of Chinese Academy of Science WIBEZD2017001-03Wenzhou Medical University KYYW201901Wenzhou Medical University KYYW201906Zhejiang Provincial Natural Science of Foundation of China LQ22E030011Zhejiang Provincial Natural Science of Foundation of China LZ19H180001
6 · The paper itself

Abstract

Polydopamine (PDA) nanoparticles have emerged as an attractive biomimetic photothermal agent in photothermal antibacterial therapy due to their ease of synthesis, good biodegradability, long-term safety, and excellent photostability. However, the therapeutic effects of PDA nanoparticles are generally limited by the low photothermal conversion efficiency (PCE). Herein, PDA@Ag nanoparticles are synthesized via growing Ag on the surface of PDA nanoparticles and then encapsulated into a cationic guar gum (CG) hydrogel network. The optimized CG/PDA@Ag platform exhibits a high PCE (38.2%), which is more than two times higher than that of pure PDA (16.6%). More importantly, the formulated CG/PDA@Ag hydrogel with many active groups can capture and kill bacteria through effective interactions between hydrogel and bacteria, thereby benefiting the antibacterial effect. As anticipated, the designed CG/PDA@Ag system combined the advantages of PDA@Ag nanoparticles (high PCE) and hydrogel (preventing aggregation of PDA@Ag nanoparticles and possessing inherent antibacterial ability) is demonstrated to have superior antibacterial efficacy both in vitro and in vivo. This study develops a facile approach to boost the PCE of PDA for photothermal antibacterial therapy, providing a significant step forward in advancing the application of PDA nano-photothermal agents.

Indexed as

Bacterial InfectionsMetal NanoparticlesAnti-Bacterial AgentsHumansHydrogelsIndolesPolymersSilverWound HealingAnti-Bacterial AgentsHydrogelsIndolespolydopaminePolymersSilverAg-decorated polydopamine nanoparticlesantibacterial therapyphotothermal agentphotothermal conversion efficiencypolysaccharide hydrogel

Identifiers

PMID35191211
PMCPMC9008420
OpenAlexW4212772261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.