Evidence map›Paper›PMID 35190959›Full record

ReviewJournal of assisted reproduction and genetics2022

Revisiting selected ethical aspects of current clinical in vitro fertilization (IVF) practice.

Anja von Schondorf-Gleicher, Lyka Mochizuki, Raoul Orvieto, Pasquale Patrizio, Arthur S Caplan, Norbert Gleicher

Abstract readReview
In one paragraph

Review in Journal of assisted reproduction and genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Eclampsia,Translational pediatrics · 2023
    Article
  9. Novel embryo selection strategies-finding the right balance.Frontiers in reproductive health · 2023
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anja von Schondorf-GleicherThe Center for Human Reproduction, New York, NY, 10021, USA.
Lyka MochizukiThe Center for Human Reproduction, New York, NY, 10021, USA.
Raoul OrvietoChaim Sheba Medical Center, Infertility and IVF Unit, Department of Obstetrics and Gynecology, Sackler Medical Faculty, Tel Aviv University, Tel-Aviv, Israel.
Pasquale PatrizioDepartment of Obstetrics, Gynecology and Reproductive Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.
Arthur S CaplanDivision of Medical Ethics, New York University Langone Medical Center and NYU Grossman School of Medicine, New York, NY, USA.
Norbert GleicherThe Center for Human Reproduction, New York, NY, 10021, USA. ngleicher@thechr.com.ORCID http://orcid.org/0000-0002-0202-4167

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ethical considerations are central to all medicine though, likely, nowhere more essential than in the practice of reproductive endocrinology and infertility. Through in vitro fertilization (IVF), this is the only field in medicine involved in creating human life. IVF has, indeed, so far led to close to 10 million births worldwide. Yet, relating to substantial changes in clinical practice of IVF, the medical literature has remained surprisingly quiet over the last two decades. Major changes especially since 2010, however, call for an updated commentary. Three key changes deserve special notice: Starting out as a strictly medical service, IVF in recent years, in efforts to expand female reproductive lifespans in a process given the term "planned" oocyte cryopreservation, increasingly became more socially motivated. The IVF field also increasingly underwent industrialization and commoditization by outside financial interests. Finally, at least partially driven by industrialization and commoditization, so-called add-ons, the term describing mostly unvalidated tests and procedures added to IVF since 2010, have been held responsible for worldwide declines in fresh, non-donor live birthrates after IVF, to levels not seen since the mid-1990s. We here, therefore, do not offer a review of bioethical considerations regarding IVF as a fertility treatment, but attempt to point out ethical issues that arose because of major recent changes in clinical IVF practice.

Indexed as

Fertilization in VitroInfertilityCryopreservationFemaleFertilityHumansOocytesAdd-ons to IVFCryopreservationEgg freezingEmbryosEthicsFertility preservationGametesIn vitro fertilization (IVF)OocytesPreimplantation genetic testing for aneuploidy (PGT-a)

Identifiers

PMID35190959
PMCPMC8995227

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.