ArticleEuropean radiology experimental2022
Virtual monoenergetic images from photon-counting spectral computed tomography to assess knee osteoarthritis.
Article in European radiology experimental, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Photon-Counting CT in Musculoskeletal Radiology: Technical Principles, Clinical Applications, and Future Directions.Journal of the Belgian Society of Radiology · 2026Review
- Photon-counting detector CT: a disrupting innovation in medical imaging.European radiology experimental · 2025Article
- Improved visualization of electron-density dual-energy computed tomography for lumbar disc disease over the standard gray-scale type and virtual noncalcium imaging.Quantitative imaging in medicine and surgery · 2025Article
- Chances and challenges of photon-counting CT in musculoskeletal imaging.Skeletal radiology · 2024Review
- Experimental study on the effects of different exposure conditions and contrast agent concentrations on spectral computed tomography virtual non-contrast images.Quantitative imaging in medicine and surgery · 2024Article
- CT in osteoarthritis: its clinical role and recent advances.Skeletal radiology · 2023Review
- Clinical Applications of Photon-counting CT: A Review of Pioneer Studies and a Glimpse into the Future.Radiology · 2023Review
- Virtual monochromatic images for coronary artery imaging with a spectral photon-counting CT in comparison to dual-layer CT systems: a phantom and a preliminary human study.European radiology · 2023Article
- Osteoarthritis year in review 2022: imaging.Osteoarthritis and cartilage · 2023Review
- Quantification of cartilage and subchondral bone cysts on knee specimens based on a spectral photon-counting computed tomography.Scientific reports · 2023Article
- Early knee OA definition-what do we know at this stage? An imaging perspective.Therapeutic advances in musculoskeletal disease · 2023Review
- Optimal Conspicuity of Liver Metastases in Virtual Monochromatic Imaging Reconstructions on a Novel Photon-Counting Detector CT-Effect of keV Settings and BMI.Diagnostics (Basel, Switzerland) · 2022Article
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Authors and funding
8 authors.
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Abstract
backgroundDual-energy computed tomography has shown a great interest for musculoskeletal pathologies. Photon-counting spectral computed tomography (PCSCT) can acquire data in multiple energy bins with the potential to increase contrast, especially for soft tissues. Our objectives were to assess the value of PCSST to characterise cartilage and to extract quantitative measures of subchondral bone integrity.
methodsSeven excised human knees (3 males and 4 females; 4 normal and 3 with osteoarthritis; age 80.6 ± 14 years, mean ± standard deviation) were scanned using a clinical PCSCT prototype scanner. Tomographic image reconstruction was performed after Compton/photoelectric decomposition. Virtual monoenergetic images were generated from 40 keV to 110 keV every 10 keV (cubic voxel size 250 × 250 × 250 μm
resultsThe optimal monoenergetic images were obtained for 60 keV and 70 keV. Visual inspection revealed that these images provide sufficient spatial resolution and soft-tissue contrast to characterise surfaces, disruption, calcification of cartilage, bone osteophytes, and bone cysts. Analysis of attenuation versus energy revealed different energy fingerprint according to tissues. The volumes and numbers of bone cyst were quantified.
conclusionsVirtual monoenergetic images may provide direct visualisation of both cartilage and bone details. Thus, unenhanced PCSCT appears to be a new modality for characterising the knee joint with the potential to increase the diagnostic capability of computed tomography for joint diseases and osteoarthritis.
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