Evidence map›Paper›PMID 35190851›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2022

Bone microarchitecture impairment in prolactinoma patients assessed by HR-pQCT.

L Wang, K Chen, L Duan, X Ke, F Gong, H Pan, H Yang, H Zhu, W Xia

Abstract read
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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

L Wang *Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking, Dongcheng District, Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Hospital, No.1 Shuaifuyuan, Wangfujing Street, 100730, Beijing, China.
K Chen *Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking, Dongcheng District, Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Hospital, No.1 Shuaifuyuan, Wangfujing Street, 100730, Beijing, China.
L DuanKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking, Dongcheng District, Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Hospital, No.1 Shuaifuyuan, Wangfujing Street, 100730, Beijing, China.
X KeKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking, Dongcheng District, Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Hospital, No.1 Shuaifuyuan, Wangfujing Street, 100730, Beijing, China.
F GongKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking, Dongcheng District, Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Hospital, No.1 Shuaifuyuan, Wangfujing Street, 100730, Beijing, China.
H PanKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking, Dongcheng District, Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Hospital, No.1 Shuaifuyuan, Wangfujing Street, 100730, Beijing, China.
H YangKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking, Dongcheng District, Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Hospital, No.1 Shuaifuyuan, Wangfujing Street, 100730, Beijing, China.
H ZhuKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking, Dongcheng District, Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Hospital, No.1 Shuaifuyuan, Wangfujing Street, 100730, Beijing, China. shengxin2004@163.com.
W XiaKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking, Dongcheng District, Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Hospital, No.1 Shuaifuyuan, Wangfujing Street, 100730, Beijing, China. xiaweibo8301@163.com.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNPeking Union Medical College Hospital · CN

Funding

cams innovation fund for medical science 2016-I2M-1-002cams innovation fund for medical science 2016-I2M-1-008Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences 2019XK320005
6 · The paper itself

Abstract

purposeProlactinoma may reduce bone mineral density (BMD) and increase fracture risk, but its influence on bone microarchitecture remains to be elucidated. The purpose of this study is to evaluate bone microarchitecture parameters by high-resolution peripheral quantitative computed tomography (HR-pQCT) in prolactinoma patients.

methods31 prolactinoma patients and 62 age- and sex-matched healthy controls in our center were included, and HR-pQCT was used to evaluate their bone microarchitecture at the radius and tibia. Z-scores for bone microarchitecture parameters were calculated based on previously published reference.

resultsAfter adjusting for height and weight, prolactinoma patients had lower trabecular (- 0.011 mm, p = 0.005) and cortical thickness (- 0.116 mm, p = 0.008) and cortical area (- 6.0 mm2, p = 0.013) at radius, as well as lower trabecular (- 0.014 mm, p = 0.008) and cortical (- 0.122 mm, p = 0.022) thickness at tibia compared with the controls. Patients with higher prolactin level had more severe bone microarchitecture impairments. After adjusting for prolactin level and age, male patients had lower trabecular volumetric BMD (vBMD), trabecular number, trabecular thickness, and cortical porosity at radius, as well as lower trabecular vBMD, trabecular bone volume fraction, trabecular number, and cortical area, and higher trabecular separation at tibia compared with female patients. Z-score for radius vBMD was correlated with Z-score for areal BMD (aBMD) at lumbar and femoral neck, while Z-score for tibia vBMD was correlated with Z-score for lumbar aBMD, and some patients with vBMD Z-score below - 2.0 had aBMD Z-score within normal range.

conclusionPeripheral bone microarchitecture was impaired in prolactinoma patients, especially in patients with higher prolactin level. We compared the bone microarchitecture of prolactinoma patients and healthy controls by high-resolution peripheral quantitative computed tomography (HR-pQCT), and found that many bone microarchitecture parameters were impaired among prolactinoma patients. Such impairment was more prominent among patients with higher prolactin level.

Indexed as

Pituitary NeoplasmsProlactinomaAbsorptiometry, PhotonBone DensityFemaleFemur NeckHumansMaleProlactinRadiusTibiaProlactinBone microarchitectureHR-pQCTProlactinoma

Identifiers

PMID35190851
OpenAlexW4212867369

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.