ArticleNature medicine2022
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity.
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In one paragraph
Article in Nature medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed, 1 pooled it
18.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
159 citing papers in PubMed, 1 synthesis or guideline pooled it, 221 citations in OpenAlex.
- Understanding heterogeneity in the pathogenesis and drug responses of ulcerative colitis through single-cell and spatial transcriptomics.Frontiers in immunology · 2026Pooled it
- Serum Collagen Biomarkers Are Reflective of Tissue Specific Fibroblasts Associated With Ulcerative Colitis Activity and Treatment Response to Ustekinumab.United European gastroenterology journal · 2025Trial
- Mediators of Filgotinib Treatment Effects in Ulcerative Colitis: Exploring Circulating Biomarkers in the Phase 2b/3 SELECTION Study.Inflammatory bowel diseases · 2025Trial
- The gut microbiota-tryptophan metabolism-immune axis in inflammatory bowel disease: Mechanisms and therapeutic prospects.Human vaccines & immunotherapeutics · 2026Review
- Zbtb44-mediated transcriptional repression critically regulates colonic inflammation.Nature immunology · 2026Article
- Engineering immune cell therapies for inflammatory bowel disease: from stem cells to CAR T cells.Nature reviews. Gastroenterology & hepatology · 2026Review
- Persistence of mucosal CAR-T cells and inflammatory remodeling in enterocolitis associated with BCMA CAR-T cell therapy.Nature medicine · 2026Article
- Uninflamed colonic tissue harbors humoral activity linked to anti-TNF therapy non-response in ulcerative colitis.iScience · 2026Article
- AHR-Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg-Mediated Macrophage Efferocytosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- CAR-T cells and CAR-Treg cells for treatment of inflammatory bowel diseases.EULAR rheumatology open · 2026Review
- Beyond B cell helpers: diverse roles of peripheral helper T cells.International immunology · 2026Review
- Population-specific rare variants influence age at diagnosis in Korean inflammatory bowel disease.The Korean journal of internal medicine · 2026Article
- Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade.eLife · 2026Article
- NADAging cell · 2026Article
- Longitudinal transcriptomic analysis of mucosa in ulcerative colitis after anti-tumor necrosis factor withdrawal compared to continued treatment.Journal of Crohn's & colitis · 2026Article
- Mucin armoured diethylaminoethyl-dextran cloaked rebamipide based oral nanoformulation for the therapy of inflammatory bowel disease.Materials today. Bio · 2026Article
- Curcumin-loaded tetrahedral framework nucleic acids reshape intestinal homeostasis in ulcerative colitis by coordinating barrier repair, microbiota reconstruction, and immune modulation.Materials today. Bio · 2026Article
- Regulation of Tph cell differentiation via farnesoid X receptor of dendritic cells in inflammatory bowel disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Ocrelizumab-induced colitis: VigiBase disproportionality analysis, case reports and literature review.British journal of clinical pharmacology · 2026Review
- Local and circulating cytotoxic CD4medRxiv : the preprint server for health sciences · 2026Article
99 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
56 authors at 12 institutions in 4 countries.
Mathieu Uzzan *Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-7761-2879
Jerome C Martin *Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-0068-8776
Luka MesinLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Alexandra E LivanosHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tomas Castro-DopicoHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-6964-5478
Ruiqi HuangDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Francesca PetraliaDepartment of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Giuliana MagriTranslational Clinical Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.ORCID http://orcid.org/0000-0002-0163-3542
Shashi KumarWashington University School of Medicine, St. Louis, MO, USA.
Qing ZhaoDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Adam K RosensteinHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Minami TokuyamaHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-6488-9687
Keshav SharmaHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ryan UngaroHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Roman KosoyDepartment of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Divya JhaHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-5038-241X
Jeremy FischerPrecision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-0001-4384
Harpriya SinghHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mary E KeirBiomarker Discovery, OMNI, Genentech Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-0637-4092
Nandhini RamamoorthiBiomarker Discovery, OMNI, Genentech Inc., South San Francisco, CA, USA.
William E O'GormanOMNI Biomarker Development, Genentech Inc., South San Francisco, CA, USA.
Benjamin L CohenHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Adeeb RahmanDepartment of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Francesca CossariniPrecision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8793-5241
Akihiro SekiHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Louise LeyreHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sonia Tejedor VaqueroTranslational Clinical Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.ORCID http://orcid.org/0000-0003-2873-4981
Sakteesh GurunathanHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Emilie K GrassetPrecision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-9592-1640
Bojan LosicDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marla DubinskyHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alexander J GreensteinDepartment of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zoe GottliebHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Peter LegnaniHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
James GeorgeHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Haritz IrizarDepartment of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Aleksandar StojmirovicJanssen R&D, Spring House, Philadelphia, PA, USA.
Carrie BrodmerkelJanssen R&D, Spring House, Philadelphia, PA, USA.
Andrew KasarkisDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bruce E SandsHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Glaucia FurtadoPrecision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sergio A LiraPrecision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-6742-3089
Zewen K TuongMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.
Huaibin M KoDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-1062-2383
Andrea CeruttiPrecision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Charles O ElsonDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Menna R ClatworthyMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.
Miriam MeradPrecision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-4481-7827
Mayte Suárez-FariñasDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Carmen ArgmannDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-1110-8012
Jason A HackneyBioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5922-563X
Gabriel D VictoraLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0001-8807-348X
Gwendalyn J RandolphWashington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-9045-1195
Ephraim KenigsbergPrecision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jean Frederic ColombelHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Saurabh MehandruHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. saurabh.mehandru@mssm.edu.ORCID http://orcid.org/0000-0001-9781-2969
Icahn School of Medicine at Mount Sinai · USCenter for Information Technology · USUniversity of Cambridge · GBHospital Del Mar · ESRockefeller University · USSpringhouse · USUniversity of Alabama at Birmingham · USWashington University in St. Louis · USImmunai (United States) · USInserm · FRInstitució Catalana de Recerca i Estudis Avançats · ESUniversité Paris-Est Créteil · FR
Funding
Regulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8MDynamics of Antigen-Driven Selection in Germinal CentersR01AI119006 · NIAID · ROCKEFELLER UNIVERSITY · PI Gabriel D Victora · 2017 to 2026
$5.7MMechanisms associated with flares and remission in colitisR01DK110352 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIRA, SERGIO A. · 2017 to 2025
$5.1MDetermination of mucosal immune responses to, and infection of the gastrointestinal tract by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)R01DK123749 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CERUTTI, ANDREA, FAITH, JEREMIAH JAMES · 2020 to 2024
$4.9MB cell clonal selection in gut-associated germinal centersR01AI157137 · NIAID · ROCKEFELLER UNIVERSITY · PI Daniel S Mucida, Gabriel D Victora · 2020 to 2026
$4.8MMechanisms that alter lymphatic transport in inflammatory bowel diseaseR01AI168044 · NIAID · WASHINGTON UNIVERSITY · PI Gwendalyn J Randolph · 2022 to 2026
$2.8MMechanisms associated with diet-induced colitisR01DK121009 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIRA, SERGIO A. · 2020 to 2023
$2.4MMedical Research Council MR/N024907/1NIAID NIH HHS P01 AI061093NIAID NIH HHS R01 AI119006NIAID NIH HHS R01 AI157137NIAID NIH HHS R01 AI168044NIDDK NIH HHS R01 DK110352NIDDK NIH HHS R01 DK121009NIDDK NIH HHS R01 DK123749Wellcome TrustWellcome Trust 220268/Z/20/Z
Abstract
B cells, which are critical for intestinal homeostasis, remain understudied in ulcerative colitis (UC). In this study, we recruited three cohorts of patients with UC (primary cohort, n = 145; validation cohort 1, n = 664; and validation cohort 2, n = 143) to comprehensively define the landscape of B cells during UC-associated intestinal inflammation. Using single-cell RNA sequencing, single-cell IgH gene sequencing and protein-level validation, we mapped the compositional, transcriptional and clonotypic landscape of mucosal and circulating B cells. We found major perturbations within the mucosal B cell compartment, including an expansion of naive B cells and IgG
Indexed as
Colitis, UlcerativePlasma CellsB-LymphocytesHumansIntestinal MucosaLymphocyte CountT-Lymphocytes, Helper-Inducer
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