Evidence map›Paper›PMID 35190722›Full record

ReviewNature reviews. Molecular cell biology2022

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology.

Helmut Sies, Vsevolod V Belousov, Navdeep S Chandel, Michael J Davies, Dean P Jones, Giovanni E Mann, Michael P Murphy, Masayuki Yamamoto, Christine Winterbourn

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Molecular cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 736 papers.

0numbers the graph read from it
0cells of the map it votes in
736citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

736 citing papers in PubMed.

  1. Review
  2. Enzymatic and non-enzymatic oxidation of fibrillar collagen.Redox report : communications in free radical research · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Biochemical Adaptations ofPlant-environment interactions (Hoboken, N.J.) · 2026
    Review
  8. Article
  9. Disulphide maintenance systems and proteostasis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

676 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Helmut SiesInstitute for Biochemistry and Molecular Biology I, Faculty of Medicine, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. sies@hhu.de.ORCID http://orcid.org/0000-0002-1000-3198
Vsevolod V BelousovFederal Center of Brain Research and Neurotechnologies, Federal Medical Biological Agency, Moscow, Russia.
Navdeep S ChandelDivision of Pulmonary & Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-7208-3886
Michael J DaviesDepartment of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5196-6919
Dean P JonesDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-2090-0677
Giovanni E MannKing's British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0001-7311-2044
Michael P MurphyMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1115-9618
Masayuki YamamotoDepartment of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Christine WinterbournDepartment of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.ORCID http://orcid.org/0000-0003-4160-572X

Funding

Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
Dissecting the pathogenesis and outcomes of PSC using multi-omics by studying the exposome and genomeRC2DK118619 · NIDDK · MAYO CLINIC ROCHESTER · PI LAZARIDIS, KONSTANTINOS N · 2018 to 2022
$7.8M
U2C Experimental CoreU2CES030163 · NIEHS · EMORY UNIVERSITY · PI MORGAN, EDWARD THOMAS · 2018 to 2021
$3.6M
Cytoplasmic-nuclear redox signaling: Disruption by dietary cadmium levelsR01ES023485 · NIEHS · EMORY UNIVERSITY · PI GO KANG, YOUNG-MI, JONES, DEAN PAUL · 2014 to 2018
$1.8M
Vanadium in lung mitochondria oxidative stressR21ES031824 · NIEHS · EMORY UNIVERSITY · PI GO KANG, YOUNG-MI, JONES, DEAN PAUL · 2020 to 2021
$429k
British Heart Foundation FS/16/67/32548British Heart Foundation FS/19/25/34277Medical Research Council MC_U105663142NIDDK NIH HHS RC2 DK118619NIEHS NIH HHS P30 ES019776NIEHS NIH HHS R01 ES023485NIEHS NIH HHS R21 ES031824NIEHS NIH HHS U2C ES030163Wellcome Trust 110158/Z/15/ZWellcome Trust 110159/A/15Z
6 · The paper itself

Abstract

'Reactive oxygen species' (ROS) is a generic term that defines a wide variety of oxidant molecules with vastly different properties and biological functions that range from signalling to causing cell damage. Consequently, the description of oxidants needs to be chemically precise to translate research on their biological effects into therapeutic benefit in redox medicine. This Expert Recommendation article pinpoints key issues associated with identifying the physiological roles of oxidants, focusing on H

Indexed as

Hydrogen PeroxideOxidantsAntioxidantsOxidation-ReductionReactive Oxygen SpeciesAntioxidantsHydrogen PeroxideOxidantsReactive Oxygen Species

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.