Evidence map›Paper›PMID 35190717›Full record

ArticleNature immunology2022

Tcf1 preprograms the mobilization of glycolysis in central memory CD8

Qiang Shan, Shengen Shawn Hu, Shaoqi Zhu, Xia Chen, Vladimir P Badovinac, Weiqun Peng, Chongzhi Zang, Hai-Hui Xue

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Regulators of CD8Nature reviews. Immunology · 2026
    Review
  5. Article
  6. Review
  7. Pre-division TCF1 drop determines long-term CD8 T cell fates.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. TOX, through a glass, darkly.Frontiers in immunology · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. ECSIT facilitates memory CD8Nature cell biology · 2024
    Article
  18. Article
  19. Article
  20. Antigen exposure reshapes chromatin architecture in central memory CD8Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Qiang Shan *Center for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.
Shengen Shawn Hu *Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-9691-7344
Shaoqi ZhuDepartment of Physics, The George Washington University, Washington, DC, USA.
Xia ChenCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.
Vladimir P BadovinacDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Weiqun PengDepartment of Physics, The George Washington University, Washington, DC, USA.ORCID http://orcid.org/0000-0001-5521-9091
Chongzhi ZangCenter for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA. zang@virginia.edu.ORCID http://orcid.org/0000-0003-4812-3627
Hai-Hui XueCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA. haihui.xue@hmh-cdi.org.ORCID http://orcid.org/0000-0002-9163-7669
George Washington University · USHackensack University Medical Center · USUniversity of Virginia · USUniversity of Iowa · USVA New Jersey Health Care System · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Tcf/Lef-b-catenin in T cell identity and cancerR01AI112579 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2015 to 2026
$5.4M
Tcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6M
Memory CD8 T cell localization and protection from influenzaR01AI114543 · NIAID · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P, HARTY, JOHN T · 2015 to 2024
$4.4M
Integrative computational models for functional epigenomics and transcriptional regulationR35GM133712 · NIGMS · UNIVERSITY OF VIRGINIA · PI Chongzhi Zang · 2019 to 2026
$3.4M
Ezh2 regulates follicular helper T cell differentiationR01AI139874 · NIAID · UNIVERSITY OF IOWA · PI PENG, WEIQUN, XUE, HAI-HUI · 2018 to 2022
$2.4M
Cellular and molecular mechanisms controlling sepsis-induced immunoparalyses stateR35GM134880 · NIGMS · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P · 2020 to 2024
$1.9M
NIAID NIH HHS R01 AI112579NIAID NIH HHS R01 AI114543NIAID NIH HHS R01 AI121080NIAID NIH HHS R01 AI139874NIGMS NIH HHS R35 GM133712NIGMS NIH HHS R35 GM134880
6 · The paper itself

Abstract

The mechanisms underlying the heightened protection mediated by central memory CD8

Indexed as

CD8-Positive T-LymphocytesImmunologic MemoryAnimalsCell DifferentiationChromatinGlycolysisMiceMice, Inbred C57BLChromatin

Identifiers

PMID35190717
PMCPMC8904300
OpenAlexW4212933485

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.