ArticleBritish journal of cancer2022
Associations between diagnostic time intervals and health-related quality of life, clinical anxiety and depression in adolescents and young adults with cancer: cross-sectional analysis of the BRIGHTLIGHT cohort.
Article in British journal of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- "I never thought to bring them up to the doctor": examining symptom appraisal, help-seeking behaviors, and diagnostic delays among young adults with cancer.Cancer causes & control : CCC · 2026Article
- Diagnostic Intervals in Children, Adolescents and Young Adults with Primary Bone Sarcoma: A Systematic Review.Cancers · 2026Review
- Differences in quality of life between early onset colorectal cancer patients compared to older patients: a qualitative study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Top 10 research priorities for adolescent and young adult cancer in Canada: a James Lind Alliance priority setting partnership.BMJ open · 2026Article
- Assessing the impact of timely diagnosis on psychological outcomes and quality of life for cancer patients: A scoping review.PloS one · 2026Article
- Differences in time to treatment and impact on overall survival in adolescents and young adults with Hodgkin lymphoma.Leukemia & lymphoma · 2025Article
- Quantifying diagnostic intervals and routes to diagnosis for children and young people with cancer in the UK (Childhood Cancer Diagnosis study, CCD): a population-based observational study.The Lancet regional health. Europe · 2025Article
- The effect of comorbidities on diagnostic interval for lung cancer in England: a cohort study using electronic health record data.British journal of cancer · 2024Article
- Patterns of Prescription Medication Use Before Diagnosis of Early Age-Onset Colorectal Cancer: Population-Based Descriptive Study.JMIR cancer · 2024Article
- An Evaluation of Racial and Ethnic Representation in Research Conducted with Young Adults Diagnosed with Cancer: Challenges and Considerations for Building More Equitable and Inclusive Research Practices.Current oncology (Toronto, Ont.) · 2024Observational
- The Emotional Impact of a Cancer Diagnosis: A Qualitative Study of Adolescent and Young Adult Experience.Cancers · 2024Article
- Access to Care for Adolescents and Young Adults With Cancer in the United States: State of the Literature.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Review
- Article
- Patients' Experiences of a Sarcoma Diagnosis: A Process Mapping Exercise of Diagnostic Pathways.Cancers · 2023Article
- Psychosocial Protective and Risk Factors of Quality of Life Outcomes Among Older Adults Living With HIV.AIDS and behavior · 2023Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe association of diagnostic intervals and outcomes is poorly understood in adolescents and young adults with cancer (AYA). We investigated associations between diagnostic intervals and health-related quality of life (HRQoL), anxiety and depression in a large AYA cohort.
methodsParticipants aged 12-24 completed interviews post-diagnosis, providing data on diagnostic experiences and the patient-reported outcomes (PROs) HRQoL, anxiety and depression. Demographic and cancer information were obtained from clinical and national records. Six diagnostic intervals were considered. Relationships between intervals and PROs were examined using regression models.
resultsEight hundred and thirty participants completed interviews. In adjusted models, across 28 of 30 associations, longer intervals were associated with poorer PROs. Patient intervals (symptom onset to first seeing a GP) of ≥1 month were associated with greater depression (adjusted odds ratio (aOR):1.7, 95% Confidence Interval (CI):1.1-2.5) compared to <1 month. ≥3 pre-referral GP consultations were associated with greater anxiety (aOR:1.6, CI:1.1-2.3) compared to 1-2 consultations. Symptom onset to first oncology appointment intervals of ≥2 months was associated with impaired HRQoL (aOR:1.8, CI:1.2-2.5) compared to <2 months.
conclusionsProlonged diagnostic intervals in AYA are associated with an increased risk of impaired HRQoL, anxiety and depression. Identifying and delivering interventions for this high-risk group is a priority.
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