Evidence map›Paper›PMID 35190631›Full record

ArticleScientific reports2022

Enhanced O-GlcNAc modification induced by the RAS/MAPK/CDK1 pathway is required for SOX2 protein expression and generation of cancer stem cells.

Masahiro Shimizu, Hiroshi Shibuya, Nobuyuki Tanaka

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Nuclear Galectin-1 Drives Cancer Progression throughInternational journal of biological sciences · 2026
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  9. Biomolecules · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Masahiro ShimizuDepartment of Molecular Oncology, Institute for Advanced Medical Sciences, Nippon Medical School, Bunkyo-ku, Tokyo, 113-8602, Japan.
Hiroshi ShibuyaDepartment of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, 113-8510, Japan.
Nobuyuki TanakaDepartment of Molecular Oncology, Institute for Advanced Medical Sciences, Nippon Medical School, Bunkyo-ku, Tokyo, 113-8602, Japan. nobuta@nms.ac.jp.
Nippon Medical School · JPTokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer stem cells (CSCs) have tumour initiation, self-renewal, and long-term tumour repopulation properties, and it is postulated that differentiated somatic cells can be reprogrammed to CSCs by oncogenic signals. We previously showed that oncogenic HRAS

Indexed as

Gene ExpressionAcetylglucosamineAnimalsAntineoplastic AgentsCarcinogenesisCDC2 Protein KinaseCyclic N-OxidesEnzyme InhibitorsHumansIndolizinesMiceMitogen-Activated Protein KinasesNeoplastic Stem CellsPyridinium Compoundsras ProteinsSignal TransductionAcetylglucosamineAntineoplastic AgentsCDC2 Protein KinaseCDK1 protein, humanCyclic N-OxidesdinaciclibEnzyme InhibitorsIndolizinesMitogen-Activated Protein KinasesPyridinium Compoundsras ProteinsSOX2 protein, humanSOXB1 Transcription Factors

Identifiers

PMID35190631
PMCPMC8861017
OpenAlexW4212919370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.