ArticleScientific reports2022
In-situ x-ray fluorescence imaging of the endogenous iodine distribution in murine thyroids.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Monte carlo study of detection limit for gold nanoparticles within small animal sized object during benchtop X-ray fluorescence computed tomography.Scientific reports · 2026Article
- Comparing the Achievable Sensitivity Limits of Synchrotron-based X-ray Fluorescence Imaging versus conventional X-ray absorption imaging and comparing absorbed dose levels including PET/SPECT.Zeitschrift fur medizinische Physik · 2026Review
- CT-Based Attenuation Correction Algorithm for Quantitative L-Shell X-Ray Fluorescence Imaging of Gold Nanoparticles in Murine Tumor Tissues.Diseases (Basel, Switzerland) · 2025Article
- Nanoparticle Detection in Biology and Medicine: A Review.Biosensors · 2025Review
- Biodistribution of nanoplastics in mice: advancing analytical techniques using metal-doped plastics.Communications biology · 2025Article
- Deep learning based rapid X-ray fluorescence signal extraction and image reconstruction for preclinical benchtop X-ray fluorescence computed tomography applications.Scientific reports · 2025Article
- Numerical Study towards In Vivo Tracking of Micro-/Nanoplastic Based on X-ray Fluorescence Imaging.Biomedicines · 2024Article
- Enabling Low-Dose In Vivo Benchtop X-ray Fluorescence Computed Tomography through Deep-Learning-Based Denoising.Journal of imaging · 2024Article
- High-Spatial-Resolution Benchtop X-ray Fluorescence Imaging through Bragg-Diffraction-Based Focusing with Bent Mosaic Graphite Crystals: A Simulation Study.International journal of molecular sciences · 2024Article
- Laboratory Liquid-Jet X-ray Microscopy and X-ray Fluorescence Imaging for Biomedical Applications.International journal of molecular sciences · 2024Article
- Enabling X-ray fluorescence imaging for in vivo immune cell tracking.Scientific reports · 2023Article
- Review of Development and Recent Advances in Biomedical X-ray Fluorescence Imaging.International journal of molecular sciences · 2023Review
- Assessing Cellular Uptake of Exogenous Coenzyme QAntioxidants (Basel, Switzerland) · 2022Article
- Enabling Coarse X-ray Fluorescence Imaging Scans with Enlarged Synchrotron Beam by Means of Mosaic Crystal Defocusing Optics.International journal of molecular sciences · 2022Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
X-ray fluorescence imaging (XFI) is a non-invasive detection method of small quantities of elements, which can be excited to emit fluorescence x-ray photons upon irradiation with an incident x-ray beam. In particular, it can be used to measure nanoparticle uptake in cells and tissue, thus making it a versatile medical imaging modality. However, due to substantially increased multiple Compton scattering background in the measured x-ray spectra, its sensitivity severely decreases for thicker objects, so far limiting its applicability for tracking very small quantities under in-vivo conditions. Reducing the detection limit would enable the ability to track labeled cells, promising new insights into immune response and pharmacokinetics. We present a synchrotron-based approach for reducing the minimal detectable marker concentration by demonstrating the feasibility of XFI for measuring the yet inaccessible distribution of the endogenous iodine in murine thyroids under in-vivo conform conditions. This result can be used as a reference case for the design of future preclinical XFI applications as mentioned above.
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