SynthesisTranslational psychiatry2022
The thalamus and its subnuclei-a gateway to obsessive-compulsive disorder.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- White matter abnormalities in paediatric obsessive-compulsive disorder: a systematic review of diffusion tensor imaging studies.Brain imaging and behavior · 2023Pooled it
- Regional Cerebellar Volumetrics in Obsessive-Compulsive Disorder: An ENIGMA-OCD Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Associations among mediodorsal thalamic-ventrolateral prefrontal cortical white matter fiber dispersion and OCD-related incompleteness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Altered neurodevelopmental trajectories of brain structure in Tourette syndrome and Chronic Tic Disorders.medRxiv : the preprint server for health sciences · 2026Article
- Spatiotemporal Brain Transcriptomics Reveal Risk Gene Hot-Spots in Major Neuropsychiatric Disorders.Research square · 2025Article
- Decoding the striatum of drug-naive patients with obsessive-compulsive disorder: a transcriptome and longitudinal functional magnetic resonance imaging study.Translational psychiatry · 2025Article
- Exploring connectivity and volume alterations in the Pulvinar's subnuclei: insights into the neuropathological role in obsessive-compulsive disorder (OCD).Psychological medicine · 2025Article
- Neurobiological correlates of schizophrenia-specific and highly pleiotropic genetic risk scores for neuropsychiatric disorders.Translational psychiatry · 2025Article
- Machine learning for classification of pediatric bipolar disorder with and without psychotic symptoms based on thalamic subregional structural volume.BMC psychiatry · 2025Article
- Reduced volume of the mediodorsal and anteroventral thalamus is associated with anxiety in Parkinson's disease: A cross-sectional 7-tesla MRI study.Journal of Parkinson's disease · 2025Article
- The midline thalamic nucleus reuniens promotes compulsive-like grooming in rodents.Translational psychiatry · 2025Article
- Volumetric Assessment and Graph Theoretical Analysis of Thalamic Nuclei in Essential Tremor.Brain and behavior · 2025Article
- Distinct Volume Alterations of Thalamic Nuclei Across the Schizophrenia Spectrum.Schizophrenia bulletin · 2024Article
- Thalamic nuclei volume partially mediates the effects of aerobic capacity on fatigue in people with multiple sclerosis.Journal of neurology · 2024Article
- The Longitudinal Relationship Between Brain Morphology and Obsessive-Compulsive Symptoms in Children From the General Population.JAACAP open · 2024Article
- Effects of gene dosage and development on subcortical nuclei volumes in individuals with 22q11.2 copy number variations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure.Molecular psychiatry · 2024Article
- Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder.Journal of Zhejiang University. Science. B · 2024Article
- Role of autonomic, nociceptive, and limbic brainstem nuclei in core autism features.Autism research : official journal of the International Society for Autism Research · 2024Article
- Exploring the multidimensional nature of repetitive and restricted behaviors and interests (RRBI) in autism: neuroanatomical correlates and clinical implications.Molecular autism · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
101 authors.
Cees J WeelandAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam, The Netherlands. c.j.weeland@amsterdamumc.nl.ORCID 0000-0003-1238-3769
Selina KasprzakAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam, The Netherlands.
Niels T de JoodeAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam, The Netherlands.
Yoshinari AbeDepartment of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID 0000-0001-8348-0801
Pino AlonsoBellvitge Biomedical Research Insitute-IDIBELL, Bellvitge University Hospital, Barcelona, Spain.
Stephanie H AmeisCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada.ORCID 0000-0002-7282-6077
Alan AnticevicDepartments of Psychiatry and Neuroscience, Yale University, New Haven, CT, USA.
Paul D ArnoldThe Mathison Centre for Mental Health Research & Education, Departments of Psychiatry and Medical Genetics, Calgary, Canada.ORCID 0000-0003-2496-4624
Srinivas BalachanderOCD clinic, Department of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS), Bangalore, India.
Nerisa BanajLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
Nuria BargalloMagnetic Resonance Image Core Facility, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Marcelo C BatistuzzoDepartamento de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.ORCID 0000-0003-1347-8241
Francesco BenedettiVita-Salute San Raffaele University, Milano, Italy.ORCID 0000-0003-4949-856X
Jan C BeuckeDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Irene BollettiniPsychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy.ORCID 0000-0003-3666-3538
Vilde BreckeBergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.
Silvia BremDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.
Carolina CappiIcahn School of Medicine at Mount Sinai Department of Psychiatry, New York, NY, USA.
Yuqi ChengDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Kang Ik K ChoPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Daniel L C CostaObsessive-Compulsive Spectrum Disorders Program, Departamento e Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.ORCID 0000-0001-7916-8567
Sara DallaspeziaIRCCS Ospedale San Raffaele, Milano Italy Psychiatry, Milano, Italy.
Damiaan DenysAmsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Goi Khia EngDepartment of Psychiatry, New York University School of Medicine, New York, NY, USA.
Sónia FerreiraLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Jamie D FeusnerCentre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada.
Martine FontaineColumbia University Medical College, Columbia University, New York, NY, USA.
Jean-Paul FoucheDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Rachael G GraziopleneDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Patricia GrunerDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Mengxin HeDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.ORCID 0000-0003-2714-3565
Yoshiyuki HiranoResearch Center for Child Mental Development, Chiba University, Chiba, Japan.ORCID 0000-0003-3844-3061
Marcelo Q HoexterDepartamento de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Chaim HuyserLevvel, Academic Center for Child and Adolescent Psychiatry, Amsterdam, the Netherlands.ORCID 0000-0001-8757-3124
Hao HuShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fern Jaspers-FayerDepartment of Psychiatry, University of British Columbia, Vancouver, Canada.
Norbert KathmannDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Christian KaufmannDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Minah KimSeoul National University Hospital, Department of Neuropsychiatry, Seoul, Republic of Korea.ORCID 0000-0001-8668-0817
Kathrin KochDepartment of Neuroradiology, Klinikum rechts der Isar, Technische Universität, München, Germany.
Yoo Bin KwakDepartment of Brain and Cognitive Sciences, Seoul National University College of Natural Science, Seoul, Republic of Korea.
Jun Soo KwonDepartment of Brain and Cognitive Sciences, Seoul National University College of Natural Science, Seoul, Republic of Korea.ORCID 0000-0002-1060-1462
Luisa LazaroDepartment of Child and Adolescent Psychiatry and Psychology, Hospital Clinic, IDIBAPS, Barcelona, Spain.
Chiang-Shan R LiCIBERSAM, Barcelona, Spain.ORCID 0000-0002-9393-1212
Christine LochnerStellenbosch University, SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch, South Africa.ORCID 0000-0002-4766-3704
Rachel MarshColumbia University Medical College, Columbia University, New York, NY, USA.ORCID 0000-0003-2439-6305
Ignacio Martínez-ZalacaínBellvitge Biomedical Research Insitute-IDIBELL, Bellvitge University Hospital, Barcelona, Spain.ORCID 0000-0002-4036-0284
David Mataix-ColsDepartment of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-4545-0924
Jose M MenchónBellvitge Biomedical Research Insitute-IDIBELL, Bellvitge University Hospital, Barcelona, Spain.ORCID 0000-0002-6231-6524
Luciano MinnuziDepartment of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada.
Pedro Silva MoreiraLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Pedro MorgadoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID 0000-0003-3880-3258
Akiko NakagawaResearch Center for Child Mental Development, Chiba University, Chiba, Japan.
Takashi NakamaeGraduate School of Medical Science Kyoto Prefectural University of Medicine, Department of Psychiatry, Kyoto, Japan.ORCID 0000-0003-4265-198X
Janardhanan C NarayanaswamyOCD clinic, Department of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS), Bangalore, India.
Erika L NurmiDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
Ana E OrtizDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic, Barcelona, Spain.
Jose C ParienteMagnetic Resonance Image Core Facility, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
John PiacentiniUCLA Semel Institute, Division of Child and Adolescent Psychiatry, Los Angeles, CA, USA.ORCID 0000-0003-4195-7194
Maria Picó-PérezLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Fabrizio PirasLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID 0000-0003-3566-5494
Federica PirasLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
Christopher PittengerDepartment of Psychiatry and Yale Child Study Center, Yale University, New Haven, CT, USA.ORCID 0000-0003-2117-9321
Y C Janardhan ReddyOCD clinic, Department of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS), Bangalore, India.
Daniela Rodriguez-ManriqueTUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München, München, Germany.
Yuki SakaiDepartment of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID 0000-0003-2475-8548
Eiji ShimizuResearch Center for Child Mental Development, Chiba University, Chiba, Japan.
Venkataram ShivakumarDepartment of Integrative Medicine, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
Helen Blair SimpsonColumbia University Irving Medical College, Columbia University, New York, NY, USA.
Noam SoreniDepartment of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada.
Carles Soriano-MasBellvitge Biomedical Research Insitute-IDIBELL, Bellvitge University Hospital, Barcelona, Spain.ORCID 0000-0003-4574-6597
Nuno SousaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID 0000-0002-8755-5126
Gianfranco SpallettaIRCCS Santa Lucia Foundation, Laboratory of Neuropsychiatry, Rome, Italy.ORCID 0000-0002-7432-4249
Emily R SternDepartment of Psychiatry, New York University School of Medicine, New York, NY, USA.
Michael C StevensInstitute of Living, Hartford, CT, USA.ORCID 0000-0002-3799-5465
S Evelyn StewartDepartment of Psychiatry, University of British Columbia, Vancouver, Canada.ORCID 0000-0002-0994-6383
Philip R SzeszkoDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jumpei TakahashiDepartment of Child Psychiatry, Chiba University Hospital, Chiba, Japan.
Tais TanamatisDepartamento de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Jinsong TangDepartment of Psychiatry, Sir Run-Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Anders Lillevik ThorsenBergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.ORCID 0000-0003-2836-5223
David TolinYale University School of Medicine, New Haven, CT, USA.
Ysbrand D van der WerfAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam, The Netherlands.
Hein van MarleAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam, The Netherlands.
Guido A van WingenAmsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.ORCID 0000-0003-3076-5891
Daniela VecchioLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
G VenkatasubramanianNational Institute of Mental Health And Neurosciences, Department of Psychiatry, Bengaluru, India.ORCID 0000-0002-0949-898X
Susanne WalitzaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.
Jicai WangDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Zhen WangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-4319-5314
Anri WatanabeDepartment of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID 0000-0002-6753-1370
Lidewij H WoltersAmsterdam UMC, Department of Child and Adolescent Psychiatry, Amsterdam, the Netherlands.
Xiufeng XuDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Je-Yeon YunSeoul National University Hospital, Seoul, Republic of Korea.ORCID 0000-0002-5531-2410
Qing ZhaoShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
ENIGMA OCD Working Group
Tonya WhiteErasmus Medical Center, Department of Child and Adolescent Psychiatry/Psychology, Wytemaweg 8, 3015 GD, Rotterdam, the Netherlands.
Paul M ThompsonImaging Genetics Center, Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Dan J SteinSAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-7218-7810
Odile A van den Heuvel *Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam, The Netherlands.ORCID 0000-0002-9804-7653
Chris Vriend *Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam, The Netherlands.ORCID 0000-0003-3111-1304
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MBrain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCDR01MH116038 · NIMH · YALE UNIVERSITY · PI ANTICEVIC, ALAN, PITTENGER, CHRISTOPHER JOHN · 2019 to 2023
$3.7MNeurobiology of sensory phenomena in obsessive-compulsive disorderR01MH111794 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI STERN, EMILY R · 2017 to 2021
$3.0MCognitive-Behavioral Therapy & Glutametergic Neurometabolites in Pediatric OCDR01MH081864 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI O'NEILL, JOSEPH, PIACENTINI, JOHN C. · 2008 to 2012
$3.0MControl and Reward Circuits as Targets for Repetitive Thoughts and BehaviorsR01MH104648 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MARSH, RACHEL, SIMPSON, HELEN BLAIR · 2014 to 2017
$2.8MNeural mechanisms of perceptual abnormalities and their malleability in bodydysmorphic disorderR01MH121520 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2020 to 2025
$2.8MCognitive-Behavioral Therapy and Glutamate in Cingulate Gyrus in OCDR01MH085900 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE, O'NEILL, JOSEPH · 2011 to 2014
$1.8MThe effects of ondansetron on neural systems and symptoms associated with sensory phenomenaR33MH107589 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI STERN, EMILY R · 2017 to 2019
$1.4MNeural Mechanisms of Compulsive HoardingR01MH074934 · NIMH · HARTFORD HOSPITAL · PI TOLIN, DAVID F · 2006 to 2009
$1.0MPatient Oriented Research and Mentorship and Training in Functional Neuroimaging of Obsessive-Compulsive DisorderK24MH121571 · NIMH · YALE UNIVERSITY · PI PITTENGER, CHRISTOPHER JOHN · 2020 to 2024
$900kDissecting Causal Reasoning Abnormalities in Obsessive-Compulsive Disorder (OCD)K23MH115206 · NIMH · YALE UNIVERSITY · PI GRUNER, PATRICIA A. · 2018 to 2021
$788kNCATS NIH HHS UL1 TR001863NIBIB NIH HHS U54 EB020403NIMH NIH HHS K23 MH115206NIMH NIH HHS K24 MH121571NIMH NIH HHS R01 MH074934NIMH NIH HHS R01 MH081864NIMH NIH HHS R01 MH085900NIMH NIH HHS R01 MH104648NIMH NIH HHS R01 MH111794NIMH NIH HHS R01 MH116038NIMH NIH HHS R01 MH121520NIMH NIH HHS R21 MH101441NIMH NIH HHS R21 MH110865NIMH NIH HHS R33 MH107589Wellcome Trust
Abstract
Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T
Indexed as
Obsessive-Compulsive DisorderThalamusAdolescentAdultBrainChildHumansMagnetic Resonance Imaging
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