Evidence map›Paper›PMID 35190478›Full record

ArticleRespiratory care2022

Endotracheal Tube Size Is Associated With Mortality in Patients With Status Asthmaticus.

Markos G Kashiouris, Christopher D Chou, Yub Raj Sedhai, Randy Bitrus, Matthew M Churpek, Casey Cable, Michael L'Heureux, Arjun Mohan, Curtis N Sessler

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Markos G KashiourisDivision of Pulmonary and Critical Care, Virginia Commonwealth University, Richmond, Virginia. mkashiouris@vcu.edu.
Christopher D ChouDepartment of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia.
Yub Raj SedhaiDepartment of Internal Medicine, Community Memorial Hospital, Virginia Commonwealth University, South Hill, Virginia.
Randy BitrusDepartment of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia.
Matthew M ChurpekDivision of Allergy, Pulmonary and Critical Care, Department of Medicine, University of Wisconsin, Madison, Wisconsin.
Casey CableDivision of Pulmonary and Critical Care, Virginia Commonwealth University, Richmond, Virginia.
Michael L'HeureuxDivision of Pulmonary and Critical Care, Virginia Commonwealth University, Richmond, Virginia.
Arjun MohanDivision of Pulmonary and Critical Care, Virginia Commonwealth University, Richmond, Virginia.
Curtis N SesslerDivision of Pulmonary and Critical Care, Virginia Commonwealth University, Richmond, Virginia.
Virginia Commonwealth University · USUniversity of Wisconsin–Madison · US

Funding

Center for Clinical and Translational ResearchUL1TR000058 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2015
$12.5M
NCATS NIH HHS UL1 TR000058
6 · The paper itself

Abstract

backgroundThere is limited evidence on the clinical importance of the endotracheal tube (ETT) size selection in patients with status asthmaticus who require invasive mechanical ventilation. We set out to explore the clinical outcomes of different ETT internal diameter sizes in subjects mechanically ventilated with status asthmaticus.

methodsThis was a retrospective study of intubated and non-intubated adults admitted for status asthmaticus between 2014-2021. We examined in-hospital mortality across subgroups with different ETT sizes, as well as non-intubated subjects, using logistic and generalized linear mixed-effects models. We adjusted for demographics, Charlson comorbidities, the first Sequential Organ Failure Assessment score, intubating personnel and setting, COVID-19, and the first P

resultsWe enrolled subjects from 964 status asthmaticus admissions. The average age was 46.9 (SD 14.5) y; 63.5% of the encounters were women and 80.6% were Black. Approximately 72% of subjects (690) were not intubated. Twenty-eight percent (275) required endotracheal intubation, of which 3.3% (32) had a 7.0 mm or smaller ETT (ETT ≤ 7 group), 16.5% (159) a 7.5 mm ETT (ETT ≤ 7.5 group), and 8.6% (83) an 8.0 mm or larger ETT (ETT ≥ 8 group). The adjusted mortality was 26.7% (95% CI 13.2-40.2) for the ETT ≤ 7 group versus 14.3% ([(95% CI 6.9-21.7%],

conclusionsIntubated subjects with status asthmaticus had higher mortality than non-intubated subjects. Intubated subjects had incrementally higher observed mortality with smaller ETT sizes. Physiologic mechanisms can support this dose-response relationship.

Indexed as

COVID-19Status AsthmaticusAdultFemaleHumansIntubation, IntratrachealMiddle AgedRetrospective StudiesSARS-CoV-2airway resistancediameterdynamic hyperinflationendotracheal tube sizemortalitystatus asthmaticus

Identifiers

PMID35190478
PMCPMC9993497
OpenAlexW4212899032

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.