ArticleBMC chemistry2022
Development and validation of liquid chromatography method for simultaneous determination of multiclass seven antibiotic residues in chicken tissues.
Article in BMC chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 29 citations in OpenAlex.
- Environmental persistence of fluoroquinolones: Reverse-phase high-performance liquid chromatography-based surveillance of contamination in water, soil, and food sources.Journal of the science of food and agriculture · 2026Article
- Triadic Mn-ZnS/MOF/MIP Fluorescent Sensor for Highly Sensitive and Selective Sulfathiazole Detection.Biosensors · 2026Article
- Natural Deep Eutectic Solvent-Based Dispersive Liquid-Liquid Microextraction Coupled with UHPLC-MS/MS for the Determination of Antibiotic Residues in Food Products.Antibiotics (Basel, Switzerland) · 2026Article
- Scoping Review of Extraction Methods for Detecting β-Lactam Antibiotics in Food Products of Animal Origin.Molecules (Basel, Switzerland) · 2025Article
- Dispersive Solid-Phase Extraction and Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry-A Rapid and Accurate Method for Detecting 10 Macrolide Residues in Aquatic Products.Foods (Basel, Switzerland) · 2024Article
- Association between iron-folic acid supplementation and pregnancy-induced hypertension among pregnant women in public hospitals, Wolaita Sodo, Ethiopia 2021: a case- control study.BMC public health · 2023Article
- Article
- Review on Plant-Based Management in Combating Antimicrobial Resistance - Mechanistic Perspective.Frontiers in pharmacology · 2022Review
- Depletion of Amoxicillin Residue in Edible Tissue of Broiler Chicken by Different Cooking Methods.International journal of analytical chemistry · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntibiotics are routinely used on poultry for therapy and prevention of diseases and to enhance animal growth. The objective of this study was to develop and validate a sensitive and reliable liquid chromatography with UV detection (LC-UV) method for the simultaneous determination of seven multiclass antibiotic residues (amoxicillin, ampicillin, penicillin, sulfamethoxazole, gentamicin, ciprofloxacin, and erythromycin) in chicken tissues.
methodsThe liquid chromatography method with UV detection was optimized for complete separation of the seven selected antibiotic compounds with reversed phase and isocratic elution using Hypersil BDS-C18 (3 µm, 100 mm × 4 mm) column. The mobile phase consisted a ratio of 0.05 M Na
resultsAll the seven standard compounds were eluted within 14 min. The results for: linearity, precision, sensitivity, accuracy, specificity, decision limit (CCα), detection capability (CCβ), suitability and method robustness were validated according to the criteria of Commission Decision 2002/657/EC guidelines. Calibration plot correlation coefficients ranged from 0.9983 to 0.9998 and the percent relative standard deviations for repeated analysis were below 5% indicating acceptable method precision. The limits of detection (LODs) and quantification (LOQs) ranged from 0.098-0.255 μg kg
conclusionsThe method was found to be appropriate for simultaneous determination of five different classes of seven antibiotic residues in chicken tissues. Furthermore, this is the first instance for the simultaneous determination of seven multiclass, multi-residues analysis using LC-UV from chicken tissue samples. This is a cost-effective and alternative method with simple instrumentation approach for laboratories that lack highly specialized state-of-the-art instrumentation.
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