Evidence map›Paper›PMID 35189905›Full record

ArticleMalaria journal2022

Inferring person-to-person networks of Plasmodium falciparum transmission: are analyses of routine surveillance data up to the task?

John H Huber, Michelle S Hsiang, Nomcebo Dlamini, Maxwell Murphy, Sibonakaliso Vilakati, Nomcebo Nhlabathi, Anita Lerch, Rasmus Nielsen, Nyasatu Ntshalintshali, Bryan Greenhouse and 1 more

Abstract read
In one paragraph

Article in Malaria journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

John H HuberDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA. jhuber3@nd.edu.ORCID http://orcid.org/0000-0001-5245-5187
Michelle S HsiangDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Nomcebo DlaminiNational Malaria Elimination Programme, Ministry of Health, Manzini, Eswatini.
Maxwell MurphyDepartment of Medicine, University of California, San Francisco, CA, USA.
Sibonakaliso VilakatiNational Malaria Elimination Programme, Ministry of Health, Manzini, Eswatini.
Nomcebo NhlabathiNational Malaria Elimination Programme, Ministry of Health, Manzini, Eswatini.
Anita LerchDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.
Rasmus NielsenDepartment of Integrative Biology and Statistics, University of California, Berkeley, CA, USA.
Nyasatu NtshalintshaliClinton Health Access Initiative, Eswatini Country Office, Mbabane, Eswatini.
Bryan GreenhouseDepartment of Medicine, University of California, San Francisco, CA, USA.
T Alex PerkinsDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA. taperkins@nd.edu.

Funding

Mentoring translational scientists in international infectious disease researchK24AI144048 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bryan R Greenhouse · 2019 to 2026
$1.6M
Evaluating Re-active Surveillance Strategies for Malaria Elimination in SwazilandK23AI101012 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI HSIANG, MICHELLE SANG · 2012 to 2016
$657k
Translational Studies of Plasmodium Falciparum Infection DynamicsK23AI076614 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GREENHOUSE, BRYAN R · 2008 to 2012
$609k
bill and melinda gates foundation 1132226national institute of allergy and infectious diseases AI101012national science foundation DGE-1841556NIAID NIH HHS K23 AI076614NIAID NIH HHS K23 AI101012NIAID NIH HHS K24 AI144048university of notre dame Peggy Notebaert Premier Fellowshipuniversity of notre dame Richard
6 · The paper itself

Abstract

backgroundInference of person-to-person transmission networks using surveillance data is increasingly used to estimate spatiotemporal patterns of pathogen transmission. Several data types can be used to inform transmission network inferences, yet the sensitivity of those inferences to different data types is not routinely evaluated.

methodsThe influence of different combinations of spatial, temporal, and travel-history data on transmission network inferences for Plasmodium falciparum malaria were evaluated.

resultsThe information content of these data types may be limited for inferring person-to-person transmission networks and may lead to an overestimate of transmission. Only when outbreaks were temporally focal or travel histories were accurate was the algorithm able to accurately estimate the reproduction number under control, R

conclusionsThese results suggest that transmission network inferences made with routine malaria surveillance data should be interpreted with caution.

Indexed as

MalariaMalaria, FalciparumDisease OutbreaksHumansPlasmodium falciparumReproduction

Identifiers

PMID35189905
PMCPMC8860266

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.