ArticleBMC medicine2022
Heart rate variability is associated with left ventricular systolic, diastolic function and incident heart failure in the general population.
Article in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Cardiovascular Autonomic Neuropathy and Indices of Heart Failure in Type 2 Diabetes: The CANCAN Study.Diabetes, obesity & metabolism · 2026Article
- Association between time-domain heart rate variability, diastolic dysfunction and unplanned readmission to cardiovascular department in older type 2 diabetes mellitus patients.BMC geriatrics · 2026Article
- Heart Rate Variability Applications in Medical Specialties: A Narrative Review.Applied psychophysiology and biofeedback · 2025Review
- Article
- Association between visceral fat area and heart rate variability in high altitude migrants with OSA: the mediating effect of insulin resistance.Lipids in health and disease · 2025Article
- Development of an electrocardiographic prediction model for outflow tract idiopathic premature ventricular contraction with decreased left ventricular ejection fraction.European journal of medical research · 2025Article
- Relationship between heart rate variability and echocardiography indices of cardiac function in healthy individuals.Clinical physiology and functional imaging · 2025Article
- Heart Rate Recovery: Up to Date in Heart Failure-A Literature Review.Journal of clinical medicine · 2024Review
- An association between heart rate variability and incident heart failure in an elderly cohort.Clinical cardiology · 2024Article
- Comparison of Heart Rate Variability in Thai Older Adults with Hypertension, Pre-Hypertension, and Normotension.TheScientificWorldJournal · 2024Article
- Heart Rate Variability for Outcome Prediction in Intracerebral and Subarachnoid Hemorrhage: A Systematic Review.Journal of clinical medicine · 2023Review
- Heart rate variability and atrial fibrillation in the general population: a longitudinal and Mendelian randomization study.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Can HRV Predict Prolonged Hospitalization and Favorable or Unfavorable Short-Term Outcome in Patients with Acute Ischemic Stroke?Life (Basel, Switzerland) · 2023Article
- Wearable Biosensors in Congenital Heart Disease: Needs to Advance the Field.JACC. Advances · 2023Article
- Article
- Influence of Two Exercise Programs on Heart Rate Variability, Body Temperature, Central Nervous System Fatigue, and Cortical Arousal after a Heart Attack.International journal of environmental research and public health · 2022Article
- Relationship between dust allergen sensitization and cardiac autonomic function in patients with chronic obstructive pulmonary disease.Chronic respiratory diseaseArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHRV has mostly shown associations with systolic dysfunction and more recently, with diastolic dysfunction in Heart failure (HF) patients. But the role of sympathetic nervous system in changes of left ventricular (LV) systolic and diastolic function and new-onset HF has not been extensively studied.
methodsAmong 3157 men and 4405 women free of HF and atrial fibrillation retrospectively included from the population-based Rotterdam Study, we used linear mixed models to examine associations of RR-interval differences and standard deviation of RR-intervals corrected for heart rate (RMSSDc and SDNNc) with longitudinal changes of LV ejection fraction (LVEF), E/A ratio, left atrial (LA) diameter, E/e' ratio. Afterwards, using cox regressions, we examined their association with new-onset HF.
resultsMean (SD) age was 65 (9.95) in men and 65.7 (10.2) in women. Every unit increase in log RMSSDc was accompanied by 0.75% (95%CI:-1.11%;-0.39%) and 0.31% (- 0.60%;-0.01%) lower LVEF among men and women each year, respectively. Higher log RMSSDc was linked to 0.03 (- 0.04;-0.01) and 0.02 (- 0.03;-0.003) lower E/A and also - 1.76 (- 2.77;- 0.75) and - 1.18 (- 1.99;-0.38) lower LVM index in both sexes and 0.72 mm (95% CI: - 1.20;-0.25) smaller LA diameters in women. The associations with LVEF in women diminished after excluding HF cases during the first 3 years of follow-up. During a median follow-up of 8.7 years, hazard ratios (95%CI) for incident HF were 1.34 (1.08;1.65) for log RMSSDc in men and 1.15 (0.93;1.42) in women. SDNNc showed similar associations.
conclusionsIndices of HRV were associated with worse systolic function in men but mainly with improvement in LA size in women. Higher HRV was associated with higher risk of new-onset HF in men. Our findings highlight potential sex differences in autonomic function underlying cardiac dysfunction and heart failure in the general population.
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