Evidence map›Paper›PMID 35189860›Full record

Observational studyBMC pregnancy and childbirth2022

Obstetric outcomes in pregnant COVID-19 women: the imbalance of von Willebrand factor and ADAMTS13 axis.

Elvira Grandone, Antonella Vimercati, Felice Sorrentino, Donatella Colaizzo, Angelo Ostuni, Oronzo Ceci, Manuela Capozza, Giovanni Tiscia, Antonio De Laurenzo, Mario Mastroianno and 5 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Observational
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Elvira GrandoneThrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", Viale Cappuccini, 71013, Foggia, S. Giovanni Rotondo, Italy. e.grandone@operapadrepio.it.
Antonella VimercatiOb/Gyn Institute, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.
Felice SorrentinoOb/Gyn Institute, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
Donatella ColaizzoThrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", Viale Cappuccini, 71013, Foggia, S. Giovanni Rotondo, Italy.
Angelo OstuniImmunohematology and Transfusion Medicine Service, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, University of Bari "Aldo Moro", Bari, Italy.
Oronzo CeciOb/Gyn Institute, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.
Manuela CapozzaNeonatal Intensive Care Unit, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.
Giovanni TisciaThrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", Viale Cappuccini, 71013, Foggia, S. Giovanni Rotondo, Italy.
Antonio De LaurenzoThrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", Viale Cappuccini, 71013, Foggia, S. Giovanni Rotondo, Italy.
Mario MastroiannoScientific Direction, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", Foggia, S. Giovanni Rotondo, Italy.
Filomena CappucciThrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", Viale Cappuccini, 71013, Foggia, S. Giovanni Rotondo, Italy.
Lucia FischettiThrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", Viale Cappuccini, 71013, Foggia, S. Giovanni Rotondo, Italy.
Maurizio MargaglioneMedical Genetics, University of Foggia, Foggia, Italy.
Ettore CicinelliOb/Gyn Institute, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.
Luigi NappiOb/Gyn Institute, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
Casa Sollievo della Sofferenza · ITUniversity of Bari Aldo Moro · ITUniversity of Foggia · ITAzienda Universitaria Ospedaliera Consorziale - Policlinico Bari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThrombotic microangiopathy has been invoked as one of the most important mechanisms of damage in COVID-19 patients. Protease ADAMTS13 is a marker of microangiopathy responsible for controlling von Willebrand multimers size. Von Willebrand factor/ADAMTS13 ratio has been found impaired in COVID-19 patients outside pregnancy.

methodsWe prospectively investigated 90 pregnant women admitted to two tertiary academic hospitals in Italy with a laboratory-confirmed diagnosis of SARS-CoV-2 infection. Demographic, clinical information and routine laboratory data were collected at the hospital admission and until discharge. We investigated whether vonWillebrand /ADAMTS13 axis imbalance is a predictor of adverse outcomes. Logistic regression analysis, which controlled for potential confounders, was performed to evaluate the association between laboratory parameters and clinical outcomes.

resultsMost women (55.6%) were parae, with median gestational age at admission of 39 weeks. At hospital admission, 63.3% were asymptomatic for COVID-19 and 24.4% showed more than one sign or symptom of infection. Nulliparae with group O showed Willebrand / ADA MTS-13 ratios significantly lower than non-O, whereas in multiparae this difference was not observed. Logistic regression showed that ratio von Willebrand to ADAMTS13 was significantly and independently associated with preterm delivery (OR 1.9, 95%CI 1.1-3.5).

conclusionThis study shows an imbalance of vonWillebrand /ADAMTS13 axis in pregnant women with COVID-19, leading to a significantly higher and independent risk of preterm delivery. Monitoring these biomarkers might support decision making process to manage and follow-up pregnancies in this setting.

Indexed as

Academic Medical CentersADAMTS13 ProteinAdolescentAdultBiomarkersCOVID-19FemaleHumansItalyMiddle AgedPregnancyPregnancy ComplicationsPremature BirthSARS-CoV-2Tertiary Care CentersThrombotic MicroangiopathiesADAMTS13 ProteinADAMTS13 protein, humanBiomarkersvon Willebrand FactorAB0 blood group systemADAMTS13COVID-19Pregnancyvon Willebrand factor

Identifiers

PMID35189860
PMCPMC8860294
OpenAlexW4213190470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.