ArticleBMC gastroenterology2022
Characteristics and potential malignancy of colorectal juvenile polyps in adults: a single-center retrospective study in China.
Article in BMC gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Uncommon cause of hematochezia in older adults: a solitary juvenile polyp in the transverse colon.Journal of rural medicine : JRM · 2026Article
- Canine colorectal proliferative lesions: a retrospective study of 217 cases.BMC veterinary research · 2025Article
- Adult juvenile polyp bleeding detected by extravascular contrast leakage and treated with endoscopic clipping: A case report.World journal of gastrointestinal endoscopy · 2025Article
- Endoscopic features of solitary colorectal hamartomatous polyps: Solitary juvenile polyp and Peutz-Jeghers polyp.Endoscopy international open · 2025Article
- Establishing a nomogram on the risk of pathological escalation of intestinal intraepithelial neoplasia in patients with colorectal intraepithelial neoplasia: a retrospective study.Frontiers in medicine · 2025Article
- Characteristics and risk factor analyses of high-grade intraepithelial neoplasia in older patients with colorectal polyps.World journal of gastrointestinal oncology · 2024Article
- Mucosa color and size may indicate malignant transformation of chicken skin mucosa-positive colorectal neoplastic polyps.World journal of gastrointestinal oncology · 2024Article
- Ileal collision tumor associated with gastrointestinal bleeding: A case report and review of literature.World journal of gastrointestinal surgery · 2024Article
- Characteristics and risk factors for colorectal polyps among children in an urban area of Wenzhou, China: a retrospective case control study.BMC pediatrics · 2023Article
- Solitary juvenile polyp of the rectum with intramucosal adenocarcinoma.Clinical journal of gastroenterology · 2023Article
- A Comparison of Single and Combined Schemes of Asia-Pacific Colorectal Screening, Faecal Immunochemical and Stool Deoxyribonucleic Acid Testing for Community Colorectal Cancer Screening.Journal of multidisciplinary healthcare · 2023Article
- Can a Solitary Juvenile Polyp Be Regarded as a Nonmalignant Polyp?ACG case reports journal · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundColorectal juvenile polyps are rare and generally considered benign in adults. Carcinogenesis or neoplastic changes are rarely mentioned in the literature. We systematically evaluated the characteristics and potential malignancy of colorectal juvenile polyps in adults.
methodsWe retrospectively reviewed the medical records of 103 adults diagnosed with colorectal juvenile polyps from September 2007 to May 2020 at our hospital. The characteristics, endoscopic findings, occurrence of intraepithelial neoplasia, carcinogenesis and diagnostic value of chicken skin mucosa (CSM) were analyzed.
resultsThe average age of patients with juvenile polyps was 43.2 years (range, 19 to 78 years). A total of 101 patients (101/103, 98.1%) had a single juvenile polyp, and two patients had multiple polyps (107 polyps in total). Polyp sizes ranged from 0.5 to 5 cm. One (1/107, 0.9%) juvenile polyp was cancerous, and 7 (7/107, 6.5%) developed low-grade intraepithelial neoplasia. Neoplasia and cancerization did not appear in the two patients with multiple polyps. A 27-year-old female had a 2-cm polyp with well-differentiated adenocarcinoma in the mucosa in the sigmoid colon with erosion on the surface. CSM was observed adjacent to 17 polyps, which were all located in the rectum and sigmoid colon, and one polyp showed low-grade intraepithelial neoplasia.
conclusionsColorectal juvenile polyps occur in a wide range of locations and in variable sizes and numbers. These polyps are solitary in most patients and have neoplastic potential. CSM is not a tumorigenic marker in colorectal juvenile polyps and usually occurs in the distant colorectum. Colorectal juvenile polyps in adults may progress from low-grade intraepithelial neoplasia to high-grade intraepithelial neoplasia and then to carcinoma and should be treated when discovered and regularly followed as colorectal adenomas.
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