Evidence map›Paper›PMID 35189698›Full record

ArticlemBio2022

Electronic Cigarette Use Promotes a Unique Periodontal Microbiome.

Scott C Thomas, Fangxi Xu, Smruti Pushalkar, Ziyan Lin, Nirali Thakor, Mridula Vardhan, Zia Flaminio, Alireza Khodadadi-Jamayran, Rebeca Vasconcelos, Adenike Akapo and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 5 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 5 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. The association between self-reported vaping and the human oral microbiome: a systematic review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
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  19. Periodontal Status and Gingival Crevicular FluidJournal of clinical medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Scott C Thomas *Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.
Fangxi Xu *Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.
Smruti Pushalkar *Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.
Ziyan LinApplied Bioinformatics Labs, New York University School of Medicine, New York, New York, USA.
Nirali ThakorDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.
Mridula VardhanDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.
Zia FlaminioDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.
Alireza Khodadadi-JamayranApplied Bioinformatics Labs, New York University School of Medicine, New York, New York, USA.
Rebeca VasconcelosDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.
Adenike AkapoDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.
Erica QueirozDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.
Maria BederoffDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.
Malvin N JanalDepartment of Epidemiology & Health Promotion, New York University College of Dentistry, New York, New York, USA.
Yuqi GuoDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.
Deanna AgualloDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.
Terry GordonDepartment of Environmental Medicine, New York University School of Medicine, New York, New York, USA.
Patricia M CorbyDepartment of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Angela R KamerDepartment of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, New York, USA.
Xin Li *Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.
Deepak Saxena *Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.
New York University · USUniversity of Pennsylvania · USYork University · US

Funding

RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZELIKOFF, JUDITH TERRY · 1985 to 2020
$26.1M
Targeting Succinate Signaling Impedes Periodontitis ProgressionR01DE027074 · NIDCR · NEW YORK UNIVERSITY · PI GRAVES, DANA T, LI, XIN · 2018 to 2022
$2.6M
Air Quality, Child, and Adult Health in Homes Where E-Cigarettes Are SmokedR01HL139239 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORDON, TERRY, WEITZMAN, MICHAEL LANE · 2017 to 2020
$2.0M
Regulation of Pancreatic Oncogenesis by the Gut MicrobiomeR01CA206105 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SAXENA, DEEPAK, SIMEONE, DIANE M · 2017 to 2021
$1.9M
Modulation of oral microenvironment by E-cigarette aerosol mixturesR01DE025992 · NIDCR · NEW YORK UNIVERSITY · PI LI, XIN, SAXENA, DEEPAK · 2016 to 2019
$1.6M
The adverse chronic effects of e-cigarettes: puff profiles, sex, genetics, and flavorings as modifying factorsR01CA239253 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORDON, TERRY · 2018 to 2022
$1.5M
NCI NIH HHS R01 CA206105NCI NIH HHS R01 CA239253NHLBI NIH HHS R01 HL139239NIDCR NIH HHS R01 DE025992NIDCR NIH HHS R01 DE027074NIEHS NIH HHS P30 ES000260
6 · The paper itself

Abstract

Electronic cigarettes (e-cigs) have become prevalent as an alternative to conventional cigarette smoking, particularly in youth. E-cig aerosols contain unique chemicals which alter the oral microbiome and promote dysbiosis in ways we are just beginning to investigate. We conducted a 6-month longitudinal study involving 84 subjects who were either e-cig users, conventional smokers, or nonsmokers. Periodontal condition, cytokine levels, and subgingival microbial community composition were assessed, with periodontal, clinical, and cytokine measures reflecting cohort habit and positively correlating with pathogenic taxa (e.g., Treponema,

Indexed as

Electronic Nicotine Delivery SystemsMicrobiotaPeriodontiumVapingAdultCytokinesHumansLongitudinal StudiesPeriodontitisCytokinesdysbiosiselectronic cigarettemicrobiomeperiodontitissubgingival plaque

Identifiers

PMID35189698
PMCPMC8903898
OpenAlexW4212793294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.